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Control of breast cancer cell growth by steroids and growth factors: Interactions and mechanisms

  • William L. McGuire Memorial Symposium
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Summary

Over the past two decades, the simple model for control of breast cancer growth involving one or two factors acting directly or indirectly via endocrine pathways has turned into a complex model implicating numerous interacting factors and the diverse cell populations constituting breast tumors. Current approaches to breast cancer therapy now require integration of these multiple parameters and enhanced understanding of the different levels of their intricate interactions.

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References

  1. Beatson GT: On the treatment of inoperable cases of carcinoma of the mamma. Suggestion for a new method of treatment with illustrative cases. Lancet ii:104–107, 162-165, 1896

    Google Scholar 

  2. Huggins C, Briziarelli G, Sutton H Jr: Rapid induction of mammary carcinoma in the rat and the influence of hormone on the tumors. J Exp Med 109:25–53, 1959

    Google Scholar 

  3. Sirbasku DA: Estrogen induction of growth factors specific for hormone-responsive mammary, pituitary, and kidney tumor cells. Proc Natl Acad Sci USA 75: 3786–3790, 1978

    Google Scholar 

  4. McGuire WL, Carbone PP, Vollmer EP: Estrogen Receptors in Human Breast Cancer. Raven Press, 1975

  5. Horwitz KB, Costlow ME, McGuire WL: MCF-7: a human breast cancer cell line with estrogen, androgen, progesterone and glucocorticoid receptors. Steroids 26:785–795, 1975

    Google Scholar 

  6. Soule HD, Vasquez J, Lang A, Albert S, Brennan MA: A human cell line from a pleural effusion derived from a breast carcinoma. J Natl Cancer Inst 51:1409–1413, 1973

    Google Scholar 

  7. Keydar I, Chen L, Karby S, Weiss FR, Delarea J, Radu M, Chaicik S, Brenner HJ: Establishment and characterization of a cell line of human breast carcinoma origin. Eur J Cancer 15:659–670, 1979

    Google Scholar 

  8. Vic P, Vignon F, Derocq D, Rochefort H: Effect of estradiol on the ultrastructure of the MCF-7 human breast cancer cells in culture. Cancer Res 42:667–673, 1982

    Google Scholar 

  9. Lippman ME, Bolan G, Huff K: The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res 36:4595–4601, 1976

    Google Scholar 

  10. Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS: Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci USA 83:2496–2500, 1986

    Google Scholar 

  11. Horwitz KB, McGuire WL: Estrogen control of progesterone receptor in human breast cancer. J Biol Chem 253:2223–2228, 1978

    Google Scholar 

  12. Westley B, Rochefort H: A secreted glycoprotein induced by estrogen in human breast cancer cell lines. Cell 20:352–362, 1980

    Google Scholar 

  13. Adams DJ, Edwards DP, McGuire WL: Hormone action in human breast cancer.In McKerns KW (ed) Regulation of Gene Expression by Hormones. Plenum Press, New York, 1983, pp 1–25

    Google Scholar 

  14. Masiakowski P, Breathnach R, Bloch J, Gannon F, Krust A, Chambon P: Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res 10:7895–7903, 1982

    Google Scholar 

  15. Rochefort H, Coezy E, Joly E, Westley B, Vignon F: Hormonal control of breast cancer in cell culture.In Iacobelli S, King RJB, Lindner HR, Lippman ME (eds) Hormones and Cancer, Progress in Cancer Research and Therapy. Raven Press, New York, vol 14, 1980, pp 21–29

    Google Scholar 

  16. DeLarco EJ, Todaro GJ: Growth factors from murine sarcoma virus transformed cells. Proc Natl Acad Sci USA 75:4001–4005, 1978

    Google Scholar 

  17. Vignon F, Derocq D, Chambon M, Rochefort H: Les protéines oestrogéno-induites sécrétées par les cellules mammaires cancéreuses humaines MCF-7 stimulent leur prolifération. C R Acad Sci Paris 296:151–156, 1983

    Google Scholar 

  18. Dickson RB, McManaway ME, Lippman ME: Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth. Science 32:1540–1543, 1986

    Google Scholar 

  19. Lippman ME, Dickson RB, Gelmann EP, Rosen N, Knabbe C, Bates S, Bronzert D, Huff K, Kasid A: Growth regulation of human breast carcinoma occurs through regulated growth factor secretion. J Cell Biochem 35:1–16, 1987

    Google Scholar 

  20. Rochefort H, Capony F, Garcia M, Cavaillès V, Freiss G, Chambon M, Morisset M, Vignon F: Estrogen-induced lysosomal protease secreted by breast cancer cells. A role in carcinogenesis? J Cell Biochem 35:17–29, 1987

    Google Scholar 

  21. Butler WB, Kirkland WL, Jorgensen TL: Induction of plasminogen activator by estrogen in a human breast cancer cell line (MCF-7). Biochem Biophys Res Commun 90:1328–1334, 1979

    Google Scholar 

  22. Morisset M, Capony F, Rochefort H: The 52 kDa estrogen-induced protein secreted by MCF-7 cells is a lysosomal protease. Biochem Biophys Res Commun 138:102–109, 1986

    Google Scholar 

  23. Huff K, Lippman ME: Hormonal control of plasminogen activator secretion in human breast cancer cells in culture. Endocrinology 114:1702–1710, 1984

    Google Scholar 

  24. Dickson RB, Huff KK, Spencer EM, Lippman ME: Induction of epidermal growth factor-related polypeptides by 17ß-estradiol in MCF-7 human breast cancer cells. Endocrinology 118:138–142, 1986

    Google Scholar 

  25. Rozengurt E, Sinnett-Smith J, Taylor-Papadimitriou J: Production of PDGF-like growth factor by breast cancer cell lines. Int J Cancer 36:246–252, 1985

    Google Scholar 

  26. Yee D, Cullen KJ, Paik S, Perdue JF, Hampton B, Schwartz A, Lippman ME, Rosen N: Insulin-like growth factor II mRNA expression in human breast cancer. Cancer Res 48:6691–6696, 1988

    Google Scholar 

  27. Lippman ME, Dickson RB, Gelmann EP, Rosen N, Knabbe C, Bates S, Bronzert D, Huff K, Kasid A: Growth regulatory peptide production by human breast carcinoma cells. J Steroid Biochem 30:52–61, 1988

    Google Scholar 

  28. Osborne CK, Arteaga CL: Autocrine and paracrine growth regulation of breast cancer: clinical implications. Breast Cancer Res Treat 15:3–11, 1990

    Google Scholar 

  29. Lippman ME, Dickson RB, Bates S, Knabbe C, Huff K, Swain S, McManaway M, Bronzert D, Kasid A, Gelmann EP: Autocrine and paracrine growth regulation of human breast cancer. Breast Cancer Res Treat 1:59–70, 1986

    Google Scholar 

  30. Vignon F, Rochefort H: Autocrine regulation of breast cancer cell growth by estrogen-induced secreted proteins and peptides.In Moudgil VK (ed) Recent Advances in Steroid Hormone Action. Walter de Gruyter & Co., Berlin, 1987, pp 405–525

    Google Scholar 

  31. Heldin CH, Westermark B, Wasteson A: Chemical and biological properties of a growth factor from human cultured osteosarcoma cells: resemblance with platelet-derived growth factor. J Cell Physiol 105:235–246, 1980

    Google Scholar 

  32. Mathieu M, Rochefort H, Barenton B, Prébois C, Vignon F: Interactions of cathepsin D and IGF-II on the IGF-II/M-6-P receptor in human breast cancer cells and possible consequences on mitogenic activity of IGF-II. Mol Endocrinol 4:1327–1335, 1990

    Google Scholar 

  33. Vignon F, Capony F, Chambon M, Freiss G, Garcia M, Rochefort H: Autocrine growth stimulation of the MCF-7 breast cancer cells by the estrogen-regulated 52K protein. Endocrinology 118:1537–1545, 1986

    Google Scholar 

  34. Cavaillès V, Augereau P, Garcia M, Rochefort H: Estrogens and growth factors induce mRNA of the 52K-pro-cathepsin-D secreted by breast cancer cells. Nucl Acids Res 16:1903–1919, 1988

    Google Scholar 

  35. Bates SE, Davidson NE, Valverius EM, Freter CE, Dickson RB, Tam JP, Kudlow JE, Lippman ME, Salomon DS: Expression of transforming growth factor α and its messenger ribonucleic acid in human breast cancer: Its regulation by estrogen and its possible significance. Mol Endocrinol 2:543–555, 1988

    Google Scholar 

  36. Osborne CK, Coronado EB, Kitten LJ, Arteaga CI, Fuqua SAW, Ramasharma K, Marshall M, Li CH: Insulin-like growth factor-II (IGF-II): a potential autocrine/paracrine growth factor for human breast cancer acting via the IGF-I receptor. Mol Endocrinol 3:1701–1709, 1989

    Google Scholar 

  37. Knabbe CK, Lippman ME, Wakefield LM, Flanders KC, Kasid A, Derynck R, Dickson RB: Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell 48:417–428, 1987

    Google Scholar 

  38. Arrick BA, Korc M, Derynck R: Differential regulation of expression of three transforming growth factor ß species in human breast cancer cell lines by estradiol. Cancer Res 50:299–303, 1990

    Google Scholar 

  39. Arteaga CL, Osborne CK: Growth inhibition of human breast cancer cellsin vitro with an antibody against the type I somatomedin receptor. Cancer Res 50:793–796, 1989

    Google Scholar 

  40. Arteaga CL, Coronado E, Osborne CK: Blockade of the epidermal growth factor receptor inhibits transforming growth factor α-induced but not estrogeninduced growth of hormone-dependent human breast cancer. Mol Endocrinol 2:1064–1069, 1988

    Google Scholar 

  41. Rohlik Q, Adams D, Kull FC, Jacobs S: An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture. Biochem Biophys Res Commun 149:276–281, 1987

    Google Scholar 

  42. Clarke R, Brünner N, Katz D, Glanz P, Dickson RB, Lippman ME, Kern FG: The effects of a constitutive production of TGF-alpha on the growth of MCF-7 human breast cancer cellsin vitro andin vivo. Mol Endocrinol 3:372–380, 1989

    Google Scholar 

  43. Garcia M, Derocq D, Pujol P, Rochefort H: Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency. Oncogene 5:1809–1814, 1990

    Google Scholar 

  44. La Rocca RV, Stein CA, Myers CE: Suramin: prototype of a new generation of antitumor compounds. Cancer Cells 2:106–115, 1990

    Google Scholar 

  45. Vignon F, Prébois C, Rochefort H: Inhibition of breast cancer growth by suramin. J Natl Cancer Inst 84:38–42, 1992

    Google Scholar 

  46. Hosang M: Suramin binds to platelet-derived growth factor and inhibits its biological activity. J Cell Biochem 29:265–273, 1985

    Google Scholar 

  47. Coffey RJ Jr, Leof EB, Shipley GD, Moses HL: Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells. J Cell Physiol 132:143–148, 1987

    Google Scholar 

  48. Berns MJJ, Schuurmans ALG, Bolt J, Lamb DJ, Foekens JA, Mulder E: Antiproliferative effects of suramin on androgen responsive tumour cells. Eur J Cancer 26:470–474, 1990

    Google Scholar 

  49. Betsholtz C, Johnson A, Heldin CH, Westermark B: Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin. Proc Natl Acad Sci USA 83:6440–6444, 1986

    Google Scholar 

  50. Huang SS, Huang JS: Rapid turnover of the plateletderived growth factor receptor insis-transformed cells and reversal by suramin. J Biol Chem 263:12608–12618, 1988

    Google Scholar 

  51. Keating MT, Williams LT: Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. Science 239:914–916, 1988

    Google Scholar 

  52. Vignon F, Bardon S, Chalbos D, Rochefort H: Antiestrogenic effect of R5020, a synthetic progestin, in human breast cancer cells in culture. J Clin Endocrinol Metab 56:317–323, 1982

    Google Scholar 

  53. Osborne CK, Bolan G, Monaco M, Lippman ME: Hormone responsive breast cancer in long-term tissue culture: effect of insulin. Proc Natl Acad Sci USA 73:4536–4540, 1976

    Google Scholar 

  54. Karey KP, Sirbasku DA: Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and estradiol. Cancer Res 48:4083–4092, 1988

    Google Scholar 

  55. Osborne CK, Hamilton B, Titus G, Livingstone RB: Epidermal growth factor stimulation of human breast cancer cells in culture. Cancer Res 40:2361–2366, 1980

    Google Scholar 

  56. Katzenellenbogen BS, Norman MJ: Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I serum and estrogen. Endocrinology 126:891–898, 1990

    Google Scholar 

  57. Nunez AM, Berry M, Imler JL, Chambon P: The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to estrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein, and the c-jun protein. EMBO J 8:823–829, 1989

    Google Scholar 

  58. Saceda M, Lippman ME, Chambon P, Lindsey RL, Ponglikitmongkol M, Puente M, Martin MB: Regulation of the estrogen receptor in MCF-7 cells by estradiol. Mol Endocrinol 2:1157–1162, 1988

    Google Scholar 

  59. Wei LL, Krett NL, Francis MD, Gordon DF, Wood WM, O'Malley BW, Horwitz KB: Multiple human progesterone receptor messenger ribonucleic acids and their autoregulation by progestin agonists and antagonists in breast cancer cells. Mol Endocrinol 2:62–72, 1988

    Google Scholar 

  60. Mukku VR, Stancel G: Regulation of epidermal growth factor receptor by estrogen. J Biol Biochem 260: 9820–9824, 1985

    Google Scholar 

  61. Stewart AJ, Johnson MD, May FEB, Westley BR: Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells. J Biol Chem 265: 21172–21178, 1990

    Google Scholar 

  62. Mathieu M, Vignon F, Capony F, Rochefort H: Estradiol down-regulates the mannose-6-phosphate/insulin-like growth factor-II receptor gene and induces cathepsin D in breast cancer cells: a receptor saturation mechanism to increase the secretion of lysosomal proenzymes. Mol Endocrinol 5:815–822, 1991

    Google Scholar 

  63. Ghahary A, Murphy LJ: Uterine insulin-like growth factor-I receptors: regulation by estrogen and variation throughout the oestrous cycle. Endocrinology 125:597–604, 1989

    Google Scholar 

  64. Cullen KJ, Yee D, Sly WS, Perdue J, Hampton B, Lippman ME, Rosen N: Insulin-like growth factor receptor expression and function in human breast cancer. Cancer Res 50:48–53, 1990

    Google Scholar 

  65. Murphy LC, Murphy LJ, Dubik D, Bell GI, Shiu RPC: Epidermal growth factor gene expression in human breast cancer cells: regulation of expression by progestins. Cancer Res 48:4555–4560, 1988

    Google Scholar 

  66. Murphy LC, Murphy LJ, Shiu RPC: Progestin regulation of EGF-receptor mRNA accumulation in T-47D human breast cancer cells. Biochem Biophys Res Commun 150:192–186, 1988

    Google Scholar 

  67. Papa V, Hartmann KKP, Rosenthal SM, Maddux BA, Siiteri PK, Goldfine ID: Progestins induce down-regulation of insulin-like growth factor-I (IGF-I) receptors in human breast cancer cells: potential autocrine role of IGF-II. Mol Endocrinol 5:709–717, 1991

    Google Scholar 

  68. Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID: Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells. Cancer Res 50:7858–7862, 1990

    Google Scholar 

  69. Sumida C, Pasqualini JR: Antiestrogens antagonize the stimulatory effect of epidermal growth factor on the induction of progesterone receptor in fetal uterine cells in culture. Endocrinology 124:591–597, 1989

    Google Scholar 

  70. Denner LA, Weigel NL, Maxwell BL, Schrader WT, O'Malley BW: Regulation of progesterone receptormediated transcription by phosphorylation. Science 250:1740–1742, 1990

    Google Scholar 

  71. Reddy KB, Mangold GL, Tandon AK, Yoneda T, Mundy GR, Zilberstein, Osborne CK: Inhibition of breast cancer cell growthin vitro by a tyrosine kinase inhibitor. Cancer Research 52:3636–3641, 1992

    Google Scholar 

  72. Vignon F, Bouton MM, Rochefort H: Antiestrogens inhibit the mitogenic effect of growth factors on breast cancer cells in the total absence of estrogens. Biochem Biophys Res Commun 146:1502–1508, 1987

    Google Scholar 

  73. Wakeling AE, Newboult E, Peters SW: Effects of antiestrogens on the proliferation of MCF-7 human breast cancer cells. J Mol Endocrinol 2:225–234, 1989

    Google Scholar 

  74. Berthois Y, Dong XF, Martin PM: Regulation of epidermal growth factor receptor by estrogen and antiestrogen in the human breast cancer cell line MCF-7. Biochem Biophys Res Commun 159:126–131, 1989

    Google Scholar 

  75. Ignar-Trowbridge DM, Nelson KG, Bidwell MC, Curtis SW, Washburn TF, McLachlan JA, Korach KS: Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor. Proc Natl Acad Sci USA 89:4658–4662, 1992

    Google Scholar 

  76. Freiss G, Prébois C, Rochefort H, Vignon F: Antisteroidal and anti-growth factor activity of antiestrogens. J Steroid Biochem Mol Biol 37:777–781, 1990

    Google Scholar 

  77. Oberg KC, Carpenter G: Dexamethasone acts as a negative regulator of epidermal growth factor receptor synthesis in fetal rat lung cells. Mol Endocrinol 3:915–922, 1989

    Google Scholar 

  78. Thompson KL, Rosner MR: Regulation of epidermal growth factor receptor gene expression by retinoic acid and epidermal growth factor. J Biol Chem 264:3230–3234, 1989

    Google Scholar 

  79. Bardon S, Vignon F, Chalbos D, Rochefort H: RU486, a progestin and glucocorticoid antagonist, inhibits the growth of breast cancer cells via the progesterone receptor. J Clin Endocrinol Metab 60:692–697, 1985

    Google Scholar 

  80. Poulin R, Dufour JM, Labrie F: Progestin inhibition of estrogen-dependent proliferation in ZR-75-1 human breast cancer cells: antagonism by insulin. Breast Cancer Res Treat 13:265–276, 1989

    Google Scholar 

  81. Murphy LC, Dotzlaw H: Endogenous growth factor expression in T47D human breast cancer cells associated with reduced sensitivity to antiproliferative effects of progestins and antiestrogens. Cancer Res 49:599–604, 1989

    Google Scholar 

  82. Pazin MJ, Williams LT: Triggering signaling cascades by receptor tyrosine kinases. Trends Biochem Sci 17:374–375, 1992

    Google Scholar 

  83. Freiss G, Rochefort H, Vignon F: Mechanisms of 4-hydroxytamoxifen anti-growth factor activity in breast cancer cells: alterations of growth factor receptor binding sites and tyrosine kinase activity. Biochem Biophys Res Commun 173:919–926, 1990

    Google Scholar 

  84. Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203–212, 1990

    Google Scholar 

  85. Mayer BJ, Jackson PK, Baltimore D: The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity. Proc Natl Acad Sci 88:627–631, 1991

    Google Scholar 

  86. Fantl WJ, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F, Williams LT: Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell 69:413–423, 1992

    Google Scholar 

  87. Glenney RG Jr: Tyrosine-phosphorylated proteins: mediators of signal transduction from the tyrosine kinases. Biochem Biophys Acta 1134:113–127, 1992

    Google Scholar 

  88. Chen WS, Lazar CS, Poenie M, Tsien RY, Gill GN, Rosenfeld MG: Requirement for intrinsic protein tyrosine kinase in the immediate and late action of the EGF receptor. Nature 328:820–823, 1987

    Google Scholar 

  89. Sainsbury JRC, Farndon JR, Harris AL: Epidermal growth factor receptors on human breast cancers. Br J Surg 72:186–188, 1985

    Google Scholar 

  90. Davidson NE, Gelmann EP, Lippman ME, Dickson RB: Epidermal growth factor receptor gene expression in estrogen receptor-positive and negative human breast cancer cell lines. Mol Endocrinol 1:216–223, 1987

    Google Scholar 

  91. Fischer EH, Charbonneau H, Tonks NK: Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science 253:401–406, 1991

    Google Scholar 

  92. Cochet C, Gill GN, Meisenhelder J, Cooper JA, Hunter T: C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factorstimulated tyrosine protein kinase activity. J Biol Chem 259:2553–2558, 1984

    Google Scholar 

  93. Daum G, Zander NF, Morse B, Hurwitz D, Schlessinger J, Fischer EH: Characterization of a human recombinant receptor-linked protein tyrosine phosphatase. J Biol Chem 266:12211–12215, 1991

    Google Scholar 

  94. Faure R, Baquiran G, Bergeron JJM, Posner BI: The dephosphorylation of insulin and epidermal growth factor receptors. J Biol Chem 267:11215–11221, 1992

    Google Scholar 

  95. Liebow C, Reilly C, Serrano M, Schally V: Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase. Proc Natl Acad Sci USA 86:2003–2007, 1989

    Google Scholar 

  96. Gruppuso PA, Mikumo R, Brautigan DL, Braun L: Growth arrest induced by transforming growth factor ß1 is accompanied by protein phosphatase activation in human keratinocytes. J Biol Chem 266:3444–3448, 1991

    Google Scholar 

  97. Shen SH, Bastien L, Posner BI, Chrétien P: A proteintyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. Nature 352:736–739, 1991

    Google Scholar 

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  1. INSERM Unit 148 on “Hormones and Cancer”, Montpellier, France

    Gilles Freiss, Christine Prébois & Françoise Vignon

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  1. Gilles Freiss
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  2. Christine Prébois
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  3. Françoise Vignon
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Freiss, G., Prébois, C. & Vignon, F. Control of breast cancer cell growth by steroids and growth factors: Interactions and mechanisms. Breast Cancer Res Tr 27, 57–68 (1993). https://doi.org/10.1007/BF00683193

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