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Assessment of the pathological grade of astrocytic gliomas using an MRI score

  • Diagnostic Neuroradiology
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Abstract

To evaluate the usefulness of an MRI score for identifying tumour tissue characteristics, 41 histologically verified supratentorial astrocytic gliomas, including 13 low-grade astrocytomas (LGA) 14 anaplastic astrocytomas (AA) and 14 glioblastoma multiformes (GBM), were examined with a 0.5T superconductive MR imager. Nine MRI criteria were used: heterogeneity (HET), cyst formation or necrosis (CN), haemorrhage (HEM), crossing the midline (CM), oedema or mass effect (EM), border definition (BD), flow void (FV), degree (CE-D) and heterogeneity (CE-HET) of contrast enhancement; Gd-enhanced T1-weighted images were obtained in 32 cases (10 LGA, 10 AA, and 12 GBM). Each of the criteria was scored and analysed statistically. The mean values of LGA, AA and GBM were 0.45±0.31, 1.18±0.20, and 1.47±0.22, respectively. The MRI score increased with the pathological grades (P<0.01–0.001). LGA had significantly lower values than AA in five (HET, CN, EM, BD, CE-D) of the nine criteria (55.6%) and lower values than GBM in all except HEM (88.9%). Three criteria (33.3%): HET, CN, and FV were significantly higher in GBM than AA. CE-D, HET, EM, CN, and CE-HET proved to be related to the pathological grade by a multiple regression analysis (P<0.001).

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References

  1. Damadian R (1971) Tumor detection by nuclear magnetic resonance. Science 171: 1151–1153

    Google Scholar 

  2. Goldsmith M, Koutcher J, Damadian R (1978) Application of the NMR malignancy index to human gastro-intestinal tumors. Cancer 41: 183–191

    Google Scholar 

  3. Englund E, Brun A, Larsson EM, Gyorffy-Wagner Z, Persson B (1986) Tumors of the central nervous system. Proton magnetic relaxation times T1 and T2 and histopathological correlates. Acta Radiol Diagn 27: 653–659

    Google Scholar 

  4. Just M, Thelen M (1988) Tissue characterization with T1, T2 and proton density values: results in 160 patients with brain tumors. Radiology 169: 779–785

    Google Scholar 

  5. Brady TJ, Buonanno FS, Pykett IL, New PFJ, Davis KR, Pohost GM, Kistler JP (1983) Preliminary clinical results of proton (1H) imaging of cranial neoplasms: In vivo measurements of T1 and mobile proton density. AJNR 4: 225–228

    Google Scholar 

  6. Komiyama M, Yagura H, Baba M, Yasui T, Hakuba A, Nishimura S, Inoue Y (1987) MR imaging: possibility of tissue characterization of brain tumors using T1 and T2 values. AJNR 8: 65–70

    Google Scholar 

  7. Burger PC, Vogel FS, Green SB, Strike TA (1985) Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications. Cancer 65: 1106–1111

    Google Scholar 

  8. Dean BL, Drayer BP, Bird CR, Flom RA, Hodak JA, Coons SW, Carey RG (1990) Gliomas: classification with MR imaging Radiology 174: 411–415

    Google Scholar 

  9. Burger PC (1986) Malignant astrocytic neoplasms: classification, pathologic anatomy, and response to therapy. Semin Oncol 13: 16–20

    Google Scholar 

  10. Nelson JS, Tsukada Y, Schoenfeld D, Fulling K, Lamarche J, Peress N (1986) Necrosis as a prognostic criterion in malignant supratentorial, astrocytic gliomas. Cancer 52: 550–554

    Google Scholar 

  11. Price AC, Runge VM, Allen JH, Partain CL, James AE Jr (1986) Primary glioma: diagnosis with magnetic resonance imaging. J Comput Tomogr 10: 325–334

    Google Scholar 

  12. Johnson PC, Hunt SJ, Drayer BP (1989) Human cerebral gliomas: correlation of postmortem MR imaging and neuropathologic findings. Radiology 170: 211–217

    Google Scholar 

  13. Laster DW, Ball MR, Moody DM, Witcofski RI, Kelly DL Jr (1984) Results of nuclear magnetic resonance with cerebral glioma. Comparison with computed tomography. Surg Neurol 22: 113–122

    Google Scholar 

  14. Wakai S, Yamakawa K, Manaka S, Takakura K (1982) Spontaneous intracranial hemorrhage caused by brain tumor: its incidence and clinical significance. Neurosurgery 10: 437–444

    Google Scholar 

  15. Kondziolka D, Bernstein M, Resch L, Tator CH, Fleming JFR, Vanderlinden RG, Schutz H (1987) Significance of hemorrhage into brain tumors: clinicopathological study. J Neurosurg 67: 852–857

    Google Scholar 

  16. Graif M, Bydder GM, Steiner RE, Niendorf P, Thomas DGT, Young IR (1985) Contrast-enhanced MR imaging of malignant brain tumors. AJNR 6: 855–862

    Google Scholar 

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Asari, S., Makabe, T., Katayama, S. et al. Assessment of the pathological grade of astrocytic gliomas using an MRI score. Neuroradiology 36, 308–310 (1994). https://doi.org/10.1007/BF00593267

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  • DOI: https://doi.org/10.1007/BF00593267

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