Abstract
The clearance of125I-sodium iothalamate,131I-sodium hippurate,99mTc-DMSA, and β2-microglobulin were determined in 20 patients with proven or suspected proximal tubular dysfunction and in 18 control patients with various renal diseases. A clear distinction in the relative99mTc-DMSA clearance was observed between patients with proximal tubulopathy (14%–35%) and control patients (>14%). A similar difference between the two groups was found in the relative β2-microglobulin clearance. Nine patients with proximal tubulopathy showed an elevated filtration fraction versus only two control patients. The renal handling of99mTc-DMSA seems to be an indicator of proximal tubular function.
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van Luijk, W.H.J., Ensing, G.J., Meijer, S. et al. Is the relative99mTc-DMSA clearance a useful marker of proximal tubular dysfunction?. Eur J Nucl Med 9, 439–442 (1984). https://doi.org/10.1007/BF00563165
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DOI: https://doi.org/10.1007/BF00563165