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Suggestive evidence for a functional unit between mast cells and substance P fibers in the rat diaphragm and mesentery

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Summary

A close spatial relationship between serotonin-containing mast cells and substance P-containing nerves was shown by immunohistochemistry using a combination of antisera specific for serotonin and substance P. This supports earlier morphological results suggesting an innervation of mast cells and pharmacological studies which postulate an influence of substance P on the release of histamine from mast cells.

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Authors and Affiliations

  1. Laboratory of Clinical Science, NIMH, Bldg. 10, Rm. 3D-48, 20205, Bethesda, MD, USA

    G. Skofitsch, J. M. Savitt & D. M. Jacobowitz

Authors
  1. G. Skofitsch
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  2. J. M. Savitt
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  3. D. M. Jacobowitz
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International Research Fellow, awarded by Fogarty International Center, Fellowship number 1 FO5 TWO 3293-01 BI

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Skofitsch, G., Savitt, J.M. & Jacobowitz, D.M. Suggestive evidence for a functional unit between mast cells and substance P fibers in the rat diaphragm and mesentery. Histochemistry 82, 5–8 (1985). https://doi.org/10.1007/BF00502084

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  • DOI: https://doi.org/10.1007/BF00502084

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