Abstract
Thirty-four joints (19 knees, 15 wrists) of 31 patients suffering from rheumatoid arthritis and related disorders were examined prior to and following intravenous administration of Gadolinium-DTPA (0.1 mmol/kg body weight). T1-weighted spin-echo sequences and the gradient-echo technique FLASH were applied. FLASH scanning was used for the registration of the time-dependent changes of signal intensity following Gd-DTPA. Synovial proliferations exhibited a rapid and marked increase of signal intensity whereas fatty tissue, bone marrow, muscle and synovial effusion demonstrated only minor changes, causing enhanced contrast between synovial pannus and joint effusion or other neighbouring structures. Within the synovial pannus, ratios (absolute signal increase) of 131.3±53.4% and 122.9±51.1% were found in T1-weighted spin-echo and in FLASH sequences respectively. The average signal increase gradient of pannus (108.2±70.6%/min) was significantly (p<0.001) different from muscle (13.4±7.8%/min), fatty tissue (10.2±8.4%/min), bone marrow (5.5±7.1%/min), and joint effusion (14.7±7.8%/min).
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aisen AM, Martel W, Ellis JH, McCune WJ (1987) Cervical spine involvement in rheumatoid arthritis: MR imaging. Radiology 165:159
Beltran J, Caudill JL, Hermann LA, Kantor SM, Hudson PN, Noto AM, Baran AS (1987) Rheumatoid arthritis: MR imaging manifestations. Radiology 165:153
Bohndorf K, Reiser M, Lochner B, Feaux de Lacroix W, Steinbrich W (1986) Magnetic resonance imaging of primary tumours and tumour-like lesions of bone. Skeletal Radiol 15:511
Brooks A, Corbett M (1977).Radiographic changes in early rheumatoid disease. Ann Rheum Dis 36:71
Crockson R, Crockson A (1974) Relationship of the erythrocyte sedimentation rate to viscosity and plasma proteins in rheumatoid arthritis. Ann Rheum Dis 33:53
Erlemann R, Reiser M, Peters PE, Wuismann P, Niendorf HP, Kunze V (1988) Time-dependent changes in signal intensity in neoplastic and inflammatory lesions of the musculoskeletal system after i.v. administration of Gd-DTPA. Radiologe 28:269
Haase A, Frahm J, Matthaei D, Haenicke W, Merbold KD (1986) FLASH imaging. Rapid NMR imaging using low flipangle pulses. J Magn Reson 67:258
Hull RG, Rennie JA, Eastmond CJ, Hutchinson JM, Smith FW (1984) Nuclear magnetic resonance tomographic imaging for popliteal cysts in rheumatoid arthritis. Ann Rheum Dis 43:56
Larsen A, Dale K, Eek M (1977) Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol (Diagn) (Stockh) 18:481
Paajannen H, Brasch RC, Schmiedl U, Ogan M (1987) Magnetic resonance imaging of local soft tissue inflammation using Gadolinium-DTPA. Acta Radiol 28:79
Reiser M, Erhart W, Bauer R, Rupp N, Lehner K, Niendorf HP, Pfändner (1986) Gd-DTPA enhanced magnetic resonance imaging in the diagnosis of inflammatory and neoplastic musculo-skeletal lesions. In: Runge VM, Claussen C, Felix R, Everette-James A (eds) Contrast agents in magnetic resonance imaging. Excerpta Medica, Amsterdam
Ropes MW, Bennett GA, Cobb S, Jocox R, Jessar RA (1958) 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis 9:175
Steinbrocker O, Träger CH, Battermann RC (1949) Therapeutic criteria in rheumatoid arthritis. JAMA 140:659
Terrier F, Hricak H, Revel D, Alpers CE, Reinhold CE, Levine J, Genant HK (1985) Magnetic resonance imaging and spectroscopy of periarticular inflammatory soft-tissue changes in experimental arthritis of the rat. Invest Radiol 20:813
Yulish BS, Liebermann JM, Newman AJ, Bryan PJ, Mulopulos GP, Modic MT (1987) Juvenile rheumatoid arthritis: Assessment with MR imaging. Radiology 165:149
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Reiser, M.F., Bongartz, G.P., Erlemann, R. et al. Gadolinium-DTPA in rheumatoid arthritis and related diseases: first results with dynamic magnetic resonance imaging. Skeletal Radiol 18, 591–597 (1989). https://doi.org/10.1007/BF00355334
Issue Date:
DOI: https://doi.org/10.1007/BF00355334