Summary
In general the 123I-IMP SPECT image of a brain tumor is visualized as a defect. Tumor case with high IMP uptake have been rarely reported. We encountered a case of primary malignant lymphoma of the brain with high IMP uptake on both early and late scans corresponding to the CT lesions. Previously reported positive cases seemed to be confined to the early scan. For the present the exact behaviour of IMP is incompletely understood, but the mechanism of high uptake has been accounted for by increased extraction and increased amine receptors at the tumor sites. We need further information to establish whether these SPECT findings were specific for primary malignant lymphoma of the brain.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Winchell HS, Baldwin RM, Lin TH (1980) Development of I-123-labeled amines for brain studies: Localization of I-123 iodophenylalkyl amines in rat brain. J Nucl Med 21: 940–946
Winchell HS, Horst WD, Braun L, Oldendorf WH, Hattner R, Parker H (1980) N-isopropyl-[123I] p-iodoamphetamine: Single-pass brain uptake and washout; Binding brain synaptosomes; and localization in dog and monkey brain. J Nucl Med 21: 947–952
Holman BL, Hill TC, Magistretti PL (1982) Brain imaging with emission computed tomography and radiolabeled amines. Prog Clin Radiol 17: 206–215
O'Leary DH, Hill TC, Lee RGL, Clouse ME, Holman BL (1983) The use of 123I-iodoamphetamine and single-photon emission computed tomography to assess local cerebral blood flow. AJNR 4: 547–549
LaFrance ND, Wagner HN, Whitehouse P, Corley E, Duelfer T (1981) Decreased accumulation of isopropyl-iodoamphetamine (I-123) in brain tumors. J Nucl Med 22: 1081–1083
Nishimura T, Hayashida K, Uehara T, Imakita S, Hashimoto K, Naruo Y, Kikuchi H (1988) Two patient with meningioma visualized as high uptake by SPECT with N-isopropyl-piodo-amphetamine (I-123). Neuroradiology 30: 351–354
Szasz IJ, Lyster D, Morrison RT (1985) Iodine-123 IMP uptake in brain metastases from lung cancer. J Nucl Med 26: 1342–1343
Ell PJ, Lui D, Cullum I, Jarritt PH, Donaghy M, Harrison MJG (1983) Cerebral blood flow studies with 123iodinelabelled amines. Lancet I: 1348–1352
Nagel JS, Ichise M, Mueller MD, Johnson KA, Engrish RJ, Kaplan WD, Schober O, Holman BL (1988) Increased iofetamine I-123 brain uptake in metastatic melanoma. Arch Neurol 45: 1126–1128
Magistretti P, Uren R, Shomer D, Blume H, Holman B, Hill T (1982) Emission tomographic scans of cerebral blood flow using I123 iodoamphetamine in epilepsy. Proc Third World Congr Nuclear Med Biol, vol 1, pp 139–143
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ohkawa, S., Yamadori, A., Mori, E. et al. A case of primary malignant lymphoma of the brain with high uptake of 123I-IMP. Neuroradiology 31, 270–272 (1989). https://doi.org/10.1007/BF00344357
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00344357