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Prevention of renal tubule re-absorption of radiometal (indium-111) labelled Fab fragment of a monoclonal antibody in mice by systemic administration of lysine

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Abstract

Systemic administration of lysine to mice injected with indium-111-labelled Fab fragment of a monoclonal antibody has been shown to reduce renal uptake/retention of the radiometal. This treatment should be applicable to clinical immunoscintigraphy and radioimmunotherapy with radiometal-labelled antibody fragments.

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Authors and Affiliations

  1. Cancer Research Laboratories, University of Nottingham, NG7 2RD, Nottingham, UK

    M. V. Pimm & S. J. Gribben

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  1. M. V. Pimm
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  2. S. J. Gribben
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Pimm, M.V., Gribben, S.J. Prevention of renal tubule re-absorption of radiometal (indium-111) labelled Fab fragment of a monoclonal antibody in mice by systemic administration of lysine. Eur J Nucl Med 21, 663–665 (1994). https://doi.org/10.1007/BF00285590

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  • DOI: https://doi.org/10.1007/BF00285590

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