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Reversible diminished renal 99mTc-DMSA uptake during converting-enzyme inhibition in a patient with renal artery stenosis

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Abstract

A patient is described who had accelerated hypertension and unilateral renal artery stenosis, and who developed further deterioration in renal function during treatment with captopril, an angiotension-I (AI) converting-enzyme inhibitor.

99mTc-DMSA uptake was greatly diminished in the stenotic kidney, although renal blood flow and handling of 131I-hippurate was preserved. Uptake of 99mTc-DMSA in the affected kidney returned after substitution of captopril by the vasodilator minoxidil, while a comparable degree of blood pressure control was maintained.

Thus, caution must be taken when interpreting results of 99mTc-DMSA scintigraphy in patients with proven or suspected renal artery stenosis treated with an AI converting-enzyme inhibiting drug. Moreover, our finding points to the importance of glomerular filtration in the renal handling of 99mTc-DMSA.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Nephrology, University Hospital, Groningen, The Netherlands

    T. K. Kremer Hovinga, J. R. Beukhof & A. J. M. Donker

  2. Department of Pediatrics, University Hospital, Groningen, The Netherlands

    W. H. J. van Luyk

  3. Department of Nuclear Medicine, University Hospital, Groningen, The Netherlands

    D. A. Piers

Authors
  1. T. K. Kremer Hovinga
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  2. J. R. Beukhof
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  3. W. H. J. van Luyk
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  4. D. A. Piers
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  5. A. J. M. Donker
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Kremer Hovinga, T.K., Beukhof, J.R., van Luyk, W.H.J. et al. Reversible diminished renal 99mTc-DMSA uptake during converting-enzyme inhibition in a patient with renal artery stenosis. Eur J Nucl Med 9, 144–146 (1984). https://doi.org/10.1007/BF00253518

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  • DOI: https://doi.org/10.1007/BF00253518

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