Abstract
A biochemical concept is proposed for a radioiodinated fatty acid avoiding high iodine background in imaging studies of the myocardium. For this approach ω-(p-123I phenyl)-pentadecanoic acid is chosen and a method for synthesis and quality control described.
Similar content being viewed by others
References
Dakin, H.D.: The mode of oxidation in the animal organism of phenyl derivatives of fatty acids. Part V. Studies on the fate of phenylvaleric acid and its derivatives. J. Biol. Chem. 6, 221–233 (1909)
Evans, J.R., Gunton, R.W., Baker, R.G., Beanlands, D.S., Spears, J.C.: Use of radioiodinated fatty acid for photoscans of the heart. Circ. Res. 16, 1–10 (1965)
Freundlieb, C., Höck, A., Vyska, K., Feinendegen, L.E., Machulla, H.-J., Stöcklin, G.: Anwendung von I-123 markierten langkettigen Fettsäuren zum Studium des Herzmuskelstoffwechsels. Radioaktive Isotope in Klinik und Forschung 13, 265–272 (1978)
Knoop, F.: Der Aufbau aromatischer Fettsäuren im Tierkörper. Freiburg: Buchdruckerei Ernst Kuttruff 1904
Kupfernagel, C.: Qualitätskontrolle und Pharmakokinetik 11C-, 18F-, 34mCl-, 77Br- und 123I-markierter Fettsäuren. Berichte der Kernforschungsanlage Jülich Jül-1551 (1978)
Machulla, H.-J., Laufer, P., Stöcklin, G.: Radioanalytical quality control of 11C-, 18F-, and 123I-labelled compounds and radiopharmaceuticals. J. Radioanal. Chem. 32, 381–400 (1976)
Machulla, H.-J., Stöcklin, G., Kupfernagel, C., Freundlieb, C., Höck, A., Vyska, K., Feinendegen, L.E.: Comparative evaluation of fatty acids labelled with 11-C, Cl-34m, Br-77, and I-123 for metabolic studies of the myocardium: concise communication. J. Nucl. Med. 19, 298–302 (1978)
Plati, J.T., Strain, W.H., Warren, S.L.: Iodinated organic compounds as contrast media for radiographic diagnoses. II. Ethyl esters of iodinated straight and branched chain phenyl fatty acids. J. Am. Chem. Soc. 65, 1273–1276 (1943)
Poe, N.D., Robinson, G.D., MacDonald, N.S.: Myocardial extraction of labelled long-chain fatty acid analogues. Proc. Soc. Exp. Biol. Med. 148, 215–218 (1975)
Thrall, J.H., Swanson, D.P., Wieland, D.M.: Teaching editorial. J. Nucl. Med. 19, 970 (1978)
Vyska, K., Höck, A., Freundlieb, C., Profant, M., Feinendegen, L.E., Machulla, H.-J., Stöcklin, G.: Myocardial imaging and measurement of myocardial fatty acid metabolism using ω-I-123-heptadecanoic acid. J. Nucl. Med. 20, 650 (1979)
Vyska, K., Freundlieb, C., Höck, A., Feinendegen, L.E., Machulla, H.-J., Stöcklin, G.: Myocardial imaging and studies of myocardial metabolism with ω-123-I-heptadecanoic acid. J. Clin. Card. (in press, 1979)
Wieland, D.M., Beierwaltes, W.H.: Synthesis of radioiodinated ω-(p-aminophenyl)-substituted fatty acids. J. Lab. Comp. Radiopharm. 16, 171 (1979)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Machulla, HJ., Marsmann, M. & Dutschka, K. Biochemical concept and synthesis of a radioiodinated phenylfatty acid for in vivo metabolic studies of the myocardium. Eur J Nucl Med 5, 171–173 (1980). https://doi.org/10.1007/BF00252480
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00252480