Abstract
In order to study “in vivo” the distribution kinetics of (-)-nicotine in animals, this molecule was labeled with carbon-11. Two synthesis methods are described. Immediately after intravenous administration of (-)-nicotine-methyl-11C in rabbits the gamma-camera shows a strong radioactivity build-up in the brain and kidneys. The biological interest of this carbon-11 labeled molecule is discussed.
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Mazière, M., Comar, D., Marazano, C. et al. Nicotine-11C: Synthesis and distribution kinetics in animals. Eur J Nucl Med 1, 255–258 (1976). https://doi.org/10.1007/BF00252173
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DOI: https://doi.org/10.1007/BF00252173