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Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications pp 181–198Cite as

Carbonic Anhydrase Expression in Kidney and Renal Cancer: Implications for Diagnosis and Treatment

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 75))

Abstract

Four different carbonic anhydrases are expressed in the human nephron, the functional unit of the kidney. These are specifically expressed in different nephron segments, emphasizing the critical role carbonic anhydrases play in maintaining the homeostasis of this crucial organ.

Whereas the localization of carbonic anhydrases in the kidney has been long established, interest in carbonic anhydrases has increased dramatically for renal cancer, in particular for the clear cell variant of renal cell carcinoma (ccRCC) because carbonic anhydrase IX is specifically expressed in ccRCC. Therefore carbonic anhydrase IX is being studied as potential diagnostic and therapeutic target, despite carbonic anhydrase IX expression in non-renal tissues.

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  1. Department of Urology, University Medical Center St Radboud, Nijmegen, The Netherlands

    Egbert Oosterwijk

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Correspondence to Egbert Oosterwijk .

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  1. Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA

    Susan C. Frost

  2. Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA

    Robert McKenna

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Oosterwijk, E. (2014). Carbonic Anhydrase Expression in Kidney and Renal Cancer: Implications for Diagnosis and Treatment. In: Frost, S., McKenna, R. (eds) Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications. Subcellular Biochemistry, vol 75. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7359-2_10

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