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Chemistry of β +-Emitting Compounds Based on Fluorine-18

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Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 222))

Abstract

Positron emission tomography (PET) is a non-invasive imaging technology which provides a unique window on the physiology and function of living organisms. It uses short-lived positron emitting isotopes to trace labelled compounds in vivo. Among those radioisotopes, fluorine-18 is a nuclide of choice: it has a longer half-life (110 min) and a positron energy (0.635 MeV) lower than the other commonly used positron emitter, carbone-11 (t1/2: 20 min, 0.96 MeV). This makes fluorine-18 very attractive in terms of synthesis time, biological studies and resolutions of PET scans. Fluorine-18 is generally produced in a cyclotron via the 20Ne(d, α)18F or 18O(p,n)18F nuclear reactions. The availability of either labelled molecular fluorine [18F]F2 or labelled fluoride [18F]F- allows flexibility in the development of synthetic routes to organic compounds. However, [18F]fluoride which is available in high specific activity is preferred for most tracer applications. The aim of this review is to emphasise the scopes and limitations of the chemistry with fluorine-18. The synthetic methodology of the different 18F-labelled precursors, their uses in rapid reactions and the potential applications of the new 18F-radiopharmaceuticals are reviewed. Apart from basic publications, most references cited have been published in the past 10 years.

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Authors and Affiliations

  1. Laboratoire de Chimie Moléculaire et Thioorganique (UMR CNRS 6507), Institut des Sciences de la Matière et du Rayonnement and Université de Caen-Basse Normandie, 6 Boulevard du Maréchal Juin, 14050, Caen Cedex, France

    Marie-Claire Lasne, Cécile Perrio & Jacques Rouden

  2. Groupement de Recherches Méthodologiques en Tomographie par Emission de Positons, CEA-LRA 10V — EA2609/DSV Université de Caen-Basse Normandie, Centre Cyceron, BP 5229, 14074, Caen, France

    Louisa Barré

  3. Département de Recherche Médicale, CEA, Service Hospitalier Frédéric Joliot, 4 place du Général Leclerc, 91401, Orsay, France

    Dirck Roeda, Frédéric Dolle & Christian Crouzel

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  1. Marie-Claire Lasne
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  3. Jacques Rouden
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  4. Louisa Barré
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  1. International Project Management Therapeutics, Schering AG, 13342, Berlin, Germany

    Werner Krause

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Lasne, MC. et al. (2002). Chemistry of β +-Emitting Compounds Based on Fluorine-18. In: Krause, W. (eds) Contrast Agents II. Topics in Current Chemistry, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-46009-8_7

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