Regular ArticleDevelopmental roles of the glypicans
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Heparan sulfate proteoglycans (HSPGs) of the ocular lens
2023, Progress in Retinal and Eye ResearchGlypican-3: A molecular marker for the detection and treatment of hepatocellular carcinoma
2020, Liver ResearchCitation Excerpt :GPC3, a 70 kDa protein, is encoded by the gene GPC3 located on the X chromosome (Xq26.2) and consists of 11 exons.4,5 GPC3 is a member of the glypican family, which has a basic structure consisting of a core protein and a heparan sulfate chain, and binds to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor.6,7 GPC3 has a cleavage site between Arg358 and Ser359 for Furin protease (Fig. 1).
MicroRNA-301b promotes the proliferation and invasion of glioma cells through enhancing activation of Wnt/β-catenin signaling via targeting Glypican-5
2019, European Journal of PharmacologyCombined haplotype blocks regression and multi-locus mixed model analysis reveals novel candidate genes associated with milk traits in dairy sheep
2019, Livestock ScienceCitation Excerpt :On OAR10, the candidate gene for PC was GPC5 (glypican-5). The gene is a cell surface proteoglycan that belongs to a protein family implicated in cell growth and differentiation (De Cat and David, 2001). In dairy cattle, the gene has been reported to be the nearest candidate gene to the significant SNPs associated with milk fatty acids (Li et al., 2014).
High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5
2018, Biochemical and Biophysical Research Communications
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Corresponding author. Center for Human Genetics, Onderwijs & Navorsing, Herestraat 49, B-3000 Leuven, Belgium. Email: [email protected]