Elsevier

NeuroImage

Volume 12, Issue 6, December 2000, Pages 757-764
NeuroImage

Rapid Communication
Assessing the Performance of SPM Analyses of Spect Neuroactivation Studies

https://doi.org/10.1006/nimg.2000.0658Get rights and content

Abstract

Several simulations of SPECT neuroactivation studies have been performed in order to determine the influence of both study size and activation focus characteristics on the detection of brain activation foci following a pixel-based statistical analysis. This was achieved by developing a methodology based on the Hoffman software brain phantom, SPECT acquisition simulation software, standard reconstruction software, and the Statistical Parametric Mapping (SPM96) package. We present results on the minimal activation levels required for focus detection. Furthermore, the improved sensitivity of the analysis resulting from the use of an iterative reconstruction technique (OSEM) with regard to the classical filtered backprojection (FBP) is assessed quantitatively, and the various physical, processing, and physiological parameters that potentially influence the detection of foci are discussed. Finally, the influence is investigated of the height threshold as implemented in SPM96 upon the size of the detected foci. Practical guidelines are proposed with regard to the number of subjects per group for SPECT activation studies following the split-dose design.

References (41)

  • F.H. Fahey et al.

    Evaluation of brain activity in FDG PET studies

    J. Comput. Assist. Tomogr.

    (1998)
  • L.G. Flores et al.

    Retention of Tc-99m ECD in delayed SPECT of the brain

    Ann. Nucl. Med.

    (1999)
  • K.J. Friston

    Statistical parametric mapping

  • K.J. Friston et al.

    Assessing the significance of focal activations using their spatial extent

    Hum. Brain Mapp.

    (1994)
  • K.J. Friston et al.

    Statistical parametric maps in functional Imaging: A general linear approach

    Hum. Brain Mapp.

    (1995)
  • G.M. Goodwin et al.

    Executive function and uptake of Tc-99m-exametazime shown by single photon emission tomography after oral idazoxan in probable Alzheimer type dementia

    Psychopharmacology

    (1997)
  • G.M. Goodwin et al.

    Uptake of Tc-99m-exametazime shown by single photon emission computed tomography before and after lithium withdrawal in bipolar patients: Associations with mania

    Br. J. Psychiatry

    (1997)
  • R.L. Harrison et al.

    A public-domain simulation system for emission tomography—Photon tracking through heterogeneous attenuation using importance sampling

    J. Nucl. Med.

    (1993)
  • E.J. Hoffman et al.

    3-D phantom to simulate cerebral blood-flow and metabolic images for PET

    IEEE Trans. Nucl. Sci.

    (1990)
  • S. Holm et al.

    Use of Tc-99m-bicisate in activation studies by split dose technique

    J. Cerebr. Blood Flow Metabol.

    (1994)
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