Elsevier

NeuroImage

Volume 6, Issue 3, October 1997, Pages 145-155
NeuroImage

Regular Article
Cortical Sites of Sustained and Divided Attention in Normal Elderly Humans

https://doi.org/10.1006/nimg.1997.0292Get rights and content

Abstract

Human brain mechanisms subserving attention have been assigned to prefrontal, midfrontal, and posterior parietal cortices, as well as to the anterior cingulate and the thalamus. To map these mechanisms in the brain, most studies have used selective attention tasks; few studies have mapped the brain under sustained or divided attention. The present study was designed to create maps of regional activity associated with sustained and divided attention using two different sensory modalities: visual checkerboard stimulation and vibrotactile stimulation of the right hand. Five cerebral PE-tomograms of15O-labeled water uptake were acquired from 16 elderly healthy subjects during sustained or divided attention to the frequency of stimulation. To locate active brain regions, thet-statistic map of relative changes in cerebral blood flow was coregistered to the subjects' averaged brain MR images and to the standard Talairach brain coordinate system. Attention was associated with activity in two sites, the right middle frontal gyrus (Brodmann area 46) and the right inferior parietal lobule (Brodmann area 40). The frontal site was more active when the subjects attended to the visual stimulus and when the attention was divided, while the parietal site was more active during attention to the vibrotactile stimulus and during simple sustained attention. Our observations are consistent with the hypotheses (1) that the right posterior parietal attention center subserves attention to several sensory modalities and (2) that a cortical network of specific neuronal sites subserves both sustained and divided attention. These hypotheses must be tested in further studies.

References (52)

  • D.L. Collins et al.

    Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space

    J. Comput. Assist. Tomogr.

    (1994)
  • M. Corbetta et al.

    Attentional modulation of neural processing of shape, color, and velocity in humans

    Science

    (1990)
  • M. Corbetta et al.

    Selective and divided attention during visual discriminations of shape, color, and speed: Functional anatomy by positron emission tomography

    J. Neurosci.

    (1991)
  • M. Corbetta et al.

    A PET study of visuospatial attention

    J. Neurosci.

    (1993)
  • M. Corbetta et al.

    Superior parietal cortex activation during spatial attention shifts and visual feature conjunction

    Science

    (1995)
  • J.A. Fodor

    The Modularity of Mind

    (1983)
  • J.A. Fodor

    Multiple review of the modularity of mind

    Behav. Brain Sci.

    (1985)
  • P.T. Fox et al.

    Stimulus rate dependence of regional cerebral blood flow in human striate cortex, demonstrated by positron emission tomography

    J. Neurophysiol.

    (1984)
  • C.D. Frith et al.

    Willed action and the prefrontal cortex in man: A study with PET

    Proc. R. Soc. London B. Biol. Sci.

    (1991)
  • L.M. Giambra

    Sustained attention in older adults: performance and processes

    Adult Information Processing: Limits on Loss

    (1993)
  • C.L. Grady et al.

    Dissociation of object and spatial vision in human extrastriate cortex: Age-related changes in activation of regional cerebral blood flow measured with [15

    J. Cogn. Neurosci.

    (1992)
  • J.V. Haxby et al.

    The functional organization of human extrastiate cortex: A PET-rCBF study of selective attention to faces and locations

    J. Neurosci.

    (1994)
  • H.J. Heinze et al.

    Combined spatial and temporal imaging of brain activity during visual selective attention in humans

    Nature

    (1994)
  • J. Hyvarinen et al.

    Function of the parietal associative area 7 as revealed from cellular discharges in alert monkeys

    Brain

    (1974)
  • E.G. Jones et al.

    An anatomical study of converging sensory pathways within the cerebral cortex of the monkey

    Brain

    (1970)
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    To whom reprint requests should be addressed at, PET Center, Aarhus University Hospital, Norrebrogade, DK-8000 Aarhus C, Denmark. Fax: (+45) 8949 3020. E-mail: [email protected]. arhusamt.dk.

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