Review ArticleCardioprotective Function of Inducible Nitric Oxide Synthase and Role of Nitric Oxide in Myocardial Ischemia and Preconditioning: an Overview of a Decade of Research☆
References (187)
- et al.
Synergism between superoxide dismutase and sodium nitrite in cardioprotection following ischemia and reperfusion
Am Heart J
(1990) - et al.
Inhibition of nitric oxide limits infarct size in the in situ rabbit heart
Biochem Biophys Res Commun
(1993) - et al.
Antiischemic effects of pirsidomine, a new nitric oxide donor
Eur J Pharmacol
(1994) The role of bradykinin and nitric oxide in the cardioprotective action of ACE inhibitors
Ann Thorac Surg
(1995)- et al.
l-arginine reduces endothelial inflammation and myocardial stunning during ischemia/reperfusion
Ann Thorac Surg
(1995) - et al.
Supplementall-arginine during cardioplegic arrest and reperfusion avoids regional postischemic injury
J Thorac Cardiovasc Surg
(1995) - et al.
l-arginine decreases infarct size in rats exposed to environmental tobacco smoke
Am Heart J
(1996) - et al.
Amelioration of severity of myocardial injury by a nitric oxide donor in rabbits fed a cholesterol-rich diet
J Am Coll Cardiol
(1996) - et al.
Effect ofl-arginine on metabolic recovery of the ischemic myocardium
Ann Thorac Surg
(1996) - et al.
Role of inducible nitric oxide synthase in pharmacological “preconditioning” with monophosphoryl lipid A
J Mol Cell Cardiol
(1997)
Endothelial stunning and myocyte recovery after reperfusion of jeopardized muscle: a role ofl-arginine blood cardioplegia
J Thorac Cardiovasc Surg
Retrograde infusion of lidocaine orl-arginine before reperfusion reduces myocardial infarct size
Ann Thorac Surg
Repeated cardiac pacing extends the time during which canine hearts are protected against ischaemia-induced arrhythmias: role of nitric oxide
J Mol Cell Cardiol
Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase
Am J Hypertens
No involvement of endogenous nitric oxide in classical ischemic preconditioning in swine
J Mol Cell Cardiol
Sustained inhibition of nitric oxide by NG-nitro-l-arginine improves myocardial function following ischemia/reperfusion in isolated perfused rat heart
J Mol Cell Cardiol
Direct detrimental effects ofl-arginine upon ischemia-reperfusion injury to myocardium
J Mol Cell Cardiol
Effect ofl-arginine cardioplegia on recovery of neonatal lamb hearts after 2 hours of cold ischemia
Ann Thorac Surg
Additive effects ofl-arginine infusion and leukocyte depletion on recovery after hypothermic ischemia in neonatal lamb hearts
J Thorac Cardiovasc Surg
Simultaneous manipulation of the nitric oxide and prostanoid pathways reduces myocardial reperfusion injury
J Thorac Cardiovasc Surg
Constitutive nitric oxide release is impaired after ischemia and reperfusion
J Thorac Cardiovasc Surg
Bradykinin protects against infarction but does not mediate ischemic preconditioning in the isolated rat heart
J Mol Cell Cardiol
Loss of pacing-induced preconditioning in rat hearts: role of nitric oxide and cholesterol-enriched diet
J Mol Cell Cardiol
Cardioprotection by cyclosporine A in experimental ischemia and reperfusion—evidence for a nitric oxide-dependent mechanism mediated by endothelin
J Mol Cell Cardiol
Vascular endothelial growth factor attenuates myocardial ischemia-reperfusion injury
Ann Thorac Surg
Interaction of nitric oxide and endothelin-1 in ischemia/reperfusion injury of rat heart
J Mol Cell Cardiol
Contribution of NO to ischemia-reperfusion injury in the saline-perfused heart: a study in endothelial NO synthase knockout mice
J Mol Cell Cardiol
Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning
J Mol Cell Cardiol
Infarct size and nitric oxide synthase in murine myocardium
J Mol Cell Cardiol
The role of nitric oxide, K+(ATP) channels, and cGMP in the preconditioning response of the rabbit
J Surg Res
Deletion of endothelial nitric oxide synthase exacerbates myocardial stunning in an isolated mouse heart model
J Surg Res
Ischemic preconditioning: from adenosine receptor to KATPchannel
Annu Rev Physiol
The late phase of preconditioning
Circ Res
Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion
J Pharmacol Exp Ther
Cardioprotective effects of authentic nitric oxide in myocardial ischemia with reperfusion
Crit Care Med
The role ofl-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat
Circulation
Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion
J Pharmacol Exp Ther
Intracoronaryl-arginine during reperfusion improves endothelial function and reduces infarct size
Am J Physiol
Role ofl-arginine-nitric oxide pathway in myocardial reoxygenation injury
Am J Physiol
Role of nitric oxide, muscarinic receptors, and the ATP-sensitive K+ channel in mediating the effects of acetylcholine to mimic preconditioning in dogs
Circ Res
Endothelial and myocardial cell protection by a cysteine-containing nitric oxide donor after myocardial ischemia and reperfusion
J Cardiovasc Pharmacol
Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs
Circulation
Inhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs
Circulation
Inhibition of nitric oxide synthase prevents myocardial protection by ramiprilat
J Pharmacol Exp Ther
The protective effect ofl-arginine on myocardial injury and endothelial function following ischaemia and reperfusion in the pig
Eur Heart J
Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide
Circulation
Myocardial and coronary endothelial protective effects of acetylcholine after myocardial ischaemia and reperfusion in rats: role of nitric oxide
Br J Pharmacol
Nitric oxide synthase protects the heart against ischemia-reperfusion injury in rabbits
J Pharmacol Exp Ther
Endogenous nitric oxide (NO) protects against ischaemia-reperfusion injury in the rabbit
Cardiovasc Res
Intracoronary nitric oxide improves postischemic coronary blood flow and myocardial contractile function
Am J Physiol
Cited by (570)
Development of the cardioprotective drugs class based on pathophysiology of myocardial infarction: A comprehensive review
2024, Current Problems in CardiologyExercise-induced late preconditioning in mice is triggered by eNOS-dependent generation of nitric oxide and activation of PKCε and is mediated by increased iNOS activity
2021, International Journal of CardiologyCitation Excerpt :This adaptation consists of an early phase, which begins within minutes but abates after 1–2 h, and a late phase, which begins 12–24 h after the stimulus and lasts for ~72 h. [1–4] Several studies have shown that a delayed cardioprotective effect similar to that induced by ischemia can be elicited by administration of various pharmacologic agents. [5–15] Although PC could be an attractive mechanism to protect myocardium in humans, [3,16–20] ischemic PC is not clinically feasible while pharmacologic PC is limited by side effects and practical considerations. [3,19,20] Recent evidence indicates that brief exposure to physical exercise also elicits a late PC effect. [21–30]
Translational insights into stem cell preconditioning: From molecular mechanisms to preclinical applications
2021, Biomedicine and PharmacotherapyUltrasound-Targeted Microbubble Cavitation with Sodium Nitrite Synergistically Enhances Nitric Oxide Production and Microvascular Perfusion
2020, Ultrasound in Medicine and BiologyNew Insights into Cardiovascular Diseases Treatment Based on Molecular Targets
2023, International Journal of Molecular Sciences
- ☆
Please address all correspondence to: Roberto Bolli, MD, Division of Cardiology, University of Louisville, Louisville, Kentucky 40292, USA. Fax: (502) 852-6454;E-mail: [email protected]