Rapid CommunicationEndotoxin-induced Cardiac Depression is Associated with Decreased Cardiac Dihydropyridine Receptors in Rabbits☆
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Role of the lectin-like domain of thrombomodulin in septic cardiomyopathy
2022, Life SciencesCitation Excerpt :This suggests that the immunomodulatory effect of the LLD of TM is mediated via its interaction with HMGB1. When trying to explain the reasons for the sepsis associated cardiac dysfunction concerning compromised diastolic relaxation as well as systolic contraction, current evidence strongly points towards impaired calcium homeostasis [39,40]. It has been proposed that calcium binds to the myofilaments and allows myocardial contraction, after which the calcium relocates into the sarcoplasmatic reticulum by a calcium-ATPase (SERCA2).
The Failing Myocardium in Sepsis
2018, Heart Failure in the Child and Young Adult: From Bench to BedsideThe Failing Myocardium in Sepsis
2017, Heart Failure in the Child and Young Adult: From Bench to BedsideMyocardial depression in sepsis: From pathogenesis to clinical manifestations and treatment
2014, Journal of Critical CareCitation Excerpt :Involvement of these channels in myocardial depression may be related to the relationship between intracellular calcium concentrations and cardiac contraction. Studies have highlighted a reduction in cardiac dihydropyridine receptors (ie, L-type calcium channels) during induced endotoxemia [11,12]; however, the relationship between decreased cell contraction and action potential duration is less conclusive [12]. Using a pig model, Stengl et al [13] demonstrated that hyperdynamic septic shock was associated with reduced L-type calcium current (ICaL) and consequent shortening of cardiac repolarization.
Myocardial dysfunction in severe sepsis and septic shock: More questions than answers?
2011, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :Two studies performed on myocytes of septic rats showed impaired calcium uptake by the sarcoplasmic reticulum113 and the impairment of the ryanodine-sensitive calcium release channels in the sarcoplasmic reticulum.114 Another study performed on rabbits showed that cardiac depression induced by endotoxin was associated with decreased cardiac dihydropyridine (mostly L-type) receptors in rabbits.115 Other studies in rabbits showed a decrease in calcium channel sensitivity as well.116,117
Cardiac pharmacokinetics and inotropic response of verapamil in rats with endotoxemia
2008, Journal of Pharmaceutical SciencesCitation Excerpt :Here we investigated the effect of LPS-induced endotoxemia on cardiac uptake and actions of verapamil. This is interesting for the following reasons: First, endotoxemia diminishes the expression of L-type calcium-channels.3 A reduced calcium influx4,5 and/or abnormalities in intramyocyte calcium accumulation6 might contribute to depression of myocardial contractility.
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Please address all correspondence to: Wilbur Y. W. Lew, Cardiology Division 9111A, Department of Veterans Affairs Medical Center, 3350 La Jolla Village Drive, San Diego, California 92161, USA.