Regular ArticleA Tissue-Specific Enhancer of the Prostate-Specific Membrane Antigen Gene, FOLH1☆
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Applications of tissue-specific and cancer-selective gene promoters for cancer diagnosis and therapy
2023, Advances in Cancer ResearchProstate-specific Membrane Antigen Biology in Lethal Prostate Cancer and its Therapeutic Implications
2022, European Urology FocusCitation Excerpt :PSMA is encoded by the FOLH1 gene located on chromosome 11p11.12 [8]. Consisting of 19 exons and 18 introns within a 60-kb region, the gene is under the control of an upstream promoter and an enhancer region present within the third intron [9]. It has been shown that SOX-7 (repressor), the TMPRSS2-ERG gene fusion (repressor), and NFATC-1 (activator) regulate FOLH1 gene expression [10–12].
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. AF007544.
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