Regular ArticleHeme Oxygenase-1 (HSP-32) and Heme Oxygenase-2 Induction in Neurons and Glial Cells of Cerebral Regions and Its Relation to Iron Accumulation after Focal Cortical Photothrombosis
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4-((5-(Tert-butyl)-3-chloro-2-hydroxybenzyl) amino)-2-hydroxybenzoic acid protects against oxygen-glucose deprivation/reperfusion injury
2018, Life SciencesCitation Excerpt :EP-induced Nrf2 activation was mediated by Akt, which could lead to subsequent HO-1 overexpression [39]. HO-1, as one of the downstream effectors of Nrf2, was decreased in the brain of experimental stroke model such as transient global ischemia [40], transient and permanent middle cerebral artery occlusion (MCAO) [41], and cortical photothrombosis [42]. Emerging evidences indicated that some treatments conferred beneficial effects against ischemic damage are associated with increased HO-1 expression [43].
Up-regulation of Heme oxygenase-1 attenuates brain damage after cerebral ischemia via simultaneous inhibition of superoxide production and preservation of NO bioavailability
2013, Experimental NeurologyCitation Excerpt :HO-1 is a rate-limiting enzyme involved with heme catabolism possessing potent anti-oxidant and anti-apoptosis effects (Le et al., 1999). HO-1 expression is significantly increased in both neuronal and non-neuronal cells after cerebral ischemia (Bidmon et al., 2001; Sutherland et al., 2009). Previous reports suggest HO-1 is induced in neurons of the cortex and striatum after transient forebrain ischemia (Takizawa et al., 1998).
Sevoflurane postconditioning involves an up-regulation of HIF-1α and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia
2012, Brain ResearchCitation Excerpt :HIF-1α, which is degraded rapidly by 26 s proteasomes in normoxia, and stabilized and transactivated to the nucleus during hypoxia, plays a key role during organ ischemia (Harms et al., 2010; Matsumoto et al., 2003; Tekin et al., 2010), by up-regulating its target gene expression (Marti et al., 2000; Shen et al., 2006). HO-1, to be a HIF-1α-regulated gene (Lee et al., 1997), is a heat-shock protein that is induced in the brain in response to focal ischemia (Bidmon et al., 2001; Otterbein et al., 2003). HO-1 converts the heme molecule into carbon monoxide, bilirubin, and iron.
Epileptogenesis after cortical photothrombotic brain lesion in rats
2007, NeuroscienceCitation Excerpt :Extravasation of blood and hemosiderin are also thought to contribute to the formation of stroke-induced epileptic foci (Witte and Freund, 1999). In the photothrombosis model of stroke, iron begins to accumulate in the cortex after 3 days (Bidmon et al., 2001). In the present experiment, iron staining was observed both in epileptic and non-epileptic rats, and thus was not an indicator of epileptogenesis after photothrombosis.