Elsevier

Cytokine

Volume 19, Issue 3, August 2002, Pages 115-120
Cytokine

Regular Articles
CYTOKINE EXPRESSION IN THREE MOUSE MODELS OF EXPERIMENTAL HEPATITIS

https://doi.org/10.1006/cyto.2002.1948Get rights and content

Abstract

The activation of T-cells and macrophages and subsequent induction of cytokines are critical factors in the development of hepatitis. Up-regulation of pro-inflammatory cytokines, e.g. TNF has been shown to induce liver injury while counter regulation by anti-inflammatory cytokines, e.g. IL-10 is protective. We compared the induction of liver injury and the expression pattern of a variety of cytokines in T-cell- versus non-T-cell-dependent mouse models of liver injury. TNF, IFNγ, IL-2, IL-4, IL-6, IL-10 and IL-12 were measured in plasma and liver tissue after either Concanavalin A (Con A), D-galactosamine/lipopolysaccharide (GalN/LPS) or high dose LPS induced liver injury. Additionally, the intra-hepatic expression of the putative pathogenicity factor high mobility group 1 protein (HMG-1) was compared in all three models.

References (26)

  • MJ Koziel

    Cytokines in viral hepatitis

    Semin Liver Dis

    (1999)
  • H Mizuhara et al.

    T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6

    J Exp Med

    (1994)
  • H Louis et al.

    Production and role of interleukin-10 in concanavalin A-induced hepatitis in mice

    Hepatology

    (1997)
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    Correspondence to: Address correspondence to: Gisa Tiegs, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuremberg, Fahrstrasse 17, D-91054 Erlangen, Germany. Tel: +49-9131-85 22 883; Fax: +49-9131-85 22 774; E-mail: [email protected]

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