TABLE 1

PFS and OS According to Total Applied Activity, Age at Diagnosis, and WHO Grade

PFS (n = 76)OS (n = 110)
CovariateUnivariateMultivariate*UnivariateMultivariate*
Total applied activity/1,000-MBq increase0.84 (0.77–0.91)0.87 (0.79–0.95)0.83 (0.77–0.90)0.83 (0.76–0.90)
Age at diagnosis/10-y increase1.11 (0.86–1.44)1.08 (0.79–1.47)1.29 (1.00–1.66)1.47 (1.07–2.00)
WHO grade IReferenceReferenceReferenceReference
WHO grade II9.06 (2.85–28.80)8.09 (1.50–26.11)2.45 (1.05–5.72)2.32 (0.95–5.63)
WHO grade III31.17 (8.50–114.34)25.78 (6.76–98.40)4.61 (1.78–11.95)2.28 (0.78–6.72)
Unknown gradeNA†NA†2.58 (0.86–7.71)2.45 (0.73–8.24)

  • ↵* Adjusted for age at diagnosis, total applied activity, WHO grade, and center effect.

  • ↵† Unknown grade (n = 5) was omitted from model; NA = not analyzed.

  • Data are HRs, with 95% CIs in parentheses.