TABLE 2

Uptake of 99mTc in Tumor-Free Areas of Organs with Highest Uptake on SPECT Images After Injection of 99mTc-ADAPT6 (Decay-Corrected)

KidneyLungsLiverSmall intestine
Time250 μg500 μg1,000 μg250 μg500 μg1,000 μg250 μg500 μg1,000 μg250 μg500 μg1,000 μg
2 h26 ± 1027 ± 1035 ± 92.7 ± 0.93.3 ± 0.82.7 ± 0.63.1 ± 0.33.2 ± 1.12.4 ± 0.81.8 ± 0.40.8 ± 0.31.0 ± 0.3
4 h31 ± 1236 ± 102.5 ± 0.82.2 ± 0.42.8 ± 1.12.4 ± 1.00.9 ± 0.31.3 ± 0.5
6 h32 ± 945 ± 112.0 ± 0.6*2.0 ± 0.4*2.6 ± 0.82.0 ± 0.70.8 ± 0.31.3 ± 0.5
24 h29 ± 1038 ± 81.4 ± 0.51.2 ± 0.42.4 ± 1.01.8 ± 0.80.6 ± 0.21.0 ± 0.3
  • * Significantly (P < 0.05) lower uptake in lungs at 6 h after injection than at 2 h.

  • Significantly (P < 0.05) lower uptake in intestinal content after injection of 500 μg than after 1,000 μg.

  • Significantly (P < 0.05) lower uptake in lungs at 24 h after injection than at 2 or 4 h.

  • Data are percentage injected radioactivity per organ (mean values and SD from all patients).