Pharmacokinetic Parameters Calculated from Blood Radioactivity in 111In-FF-21101 Administered to Cynomolgus Monkeys
| Parameter | Antibody dose | ||
| 0.04 mg/kg | 0.4 mg/kg | 4 mg/kg | |
| Cmax (%ID/mL) | 0.52 | 0.45 | 0.47 |
| AUC (%ID × h/mL) | 38.75 | 43.26 | 69.32 |
| T1/2 (h) | 147.73 | 147.10 | 241.91 |
| CL (mL/h/kg) | 0.88 | 0.68 | 0.44 |
| Vss (mL/kg) | 146.93 | 124.61 | 136.14 |
Cmax = maximum concentration; AUC = area under the curve; T1/2 = half-life; CL = clearance; Vss = volume of distribution at steady state