TABLE 2

Median Survival Time of Mice Treated with NaCl, Rituximab, 150 and 350 MBq/kg Concentrations of 177Lu-Lilotomab and Combination Therapies with 20-mm Tumor Diameter as Endpoint

Treatment groupMedian survival ± SE (d)
4×NaCl13 ± 0
4 × 10 mg/kg rituximab13 ± 3
150 MBq/kg 177Lu-lilotomab24 ± 4*
350 MBq/kg 177Lu-lilotomab38 ± 11*
150 MBq/kg 177Lu-lilotomab + rituximab31 ± 5*
350 MBq/kg 177Lu-lilotomab + rituximab70 ± 8*
  • * Significantly different from NaCl (P < 0.001).

  • Significantly different from 4 × 10 mg/kg rituximab (P < 0.01).