TABLE 1

Histopathologic Diagnosis and Clinical Data

Patient no.	Sex	Age (y)	Histo	Prim/rec	Pretreatment	MRI	FET PET	Interval between surgery and FET PET	LBR_max rim pre-OP	LBR_max rim post-OP	BTV pre-OP	BTV post-OP	Flare phenomenon	TBR_max pre-OP	TBR_max post-OP
1	M	54	AII	Rec	S	IR	CR	5	1.1	1.4	1.5	3.9	No	—	—
2	F	39	AII	Rec	S/Ch	IR	IR	6	1.1	1.3	13.6	22.4	No	2.56	1.85-
3	F	50	GBM	Prim	No	CR	CR	6	1.5	2.1	21.2	30.4	No	—	—
4	M	27	AII	Prim	No	IR	IR	6	1.2	1.4	26.7	13.0	No	2.69	2.34
5	F	77	AIII	Rec	S	IR	CR	7	1.0	1.8	2.9	12.1	No	—	—
6	M	43	OIII	Rec	S/Ch	CR	CR	8	1.0	1.5	17.0	4.8	No	—	—
7	M	45	GBM	Rec	S/R/Ch	IR	CR	9	1.2	1.2	12.6	8.3	No	—	—
8	F	15	GBM	Prim	S	NA	IR	9	1.2	2.0	39.8	57.9	No	4.54	2.38-
9	M	57	AII	Prim	No	IR	IR	10	1.2	1.1	85.3	43.9	No	2.28	2.35
10	M	42	OAIII	Rec	S/R/Ch	IR	IR	12	0.8	1.7	21.8	34.6	No	3.33	2.07-
11	M	38	AIII	Rec	S/R/Ch	IR	IR	12	1.6	1.7	14.3	18.8	No	3.08	3.09
12	M	33	GBM	Rec	S/R/Ch	IR	CR	12	1.1	1.7	17.5	27.0	No	—	—
13	M	38	OII	Rec	S	CR	IR	12	1.0	1.3	6.9	6.2	No	2.49	1.74
14	F	26	OAII	Rec	S/Ch	IR	IR	12	1.2	2.0	162.6	220.5	No	6.12	6.69
15	M	35	OAIII	Rec	S/Ch	IR	IR	13	1.1	1.3	11.7	18.4	No	3.33	3.14
16	M	51	GBM	Rec	S/R/Ch	IR	CR	13	1.0	1.3	3.7	6.9	No	—	—
17	M	53	GBM	Prim	No	CR	IR	13	1.2	2.0	20.1	81.7	Distant	1.26	3.37
18	M	39	GBM	Rec	S/R/Ch	IR	IR	13	1.1	1.6	4.0	24.3	Distant	0.99	1.82
19	F	27	AIII	Rec	S/Ch	IR	IR	13	1.0	1.5	18.0	55.8	No	2.26	1.98
20	M	71	AIII	Rec	S/R/Ch	CR	IR	13	1.0	1.4	31.8	45.5	No	2.22	2.47
21	M	30	AII	Prim	No	IR	CR	13	1.2	1.6	2.9	15.8	No	—	—
22	M	29	AIII	Rec	S/Ch	IR	IR	14	1.2	1.6	26.0	40.3	No	2.00	2,10
23	M	63	OAII	Rec	S	IR	IR	14	1.1	1.5	7.3	16.0	No	2.25	1.82
24	M	49	GBM	Rec	S/R/Ch	IR	CR	15	1.0	1.4	11.5	8.8	No	—	—
25	M	51	OAIII	Rec	S/R/Ch	IR	IR	15	1.5	1.8	81.4	62.5	Local	3.61	5.28
26	F	55	GBM	Rec	S/R/Ch	CR	CR	15	1.1	1.4	18.9	9.0	No	—	—
27	M	54	GBM	Rec	S/R/Ch	IR	IR	15	0.9	1.6	71.0	59.9	No	3.18	2.46
28	F	74	GBM	Rec	S/R/Ch	CR	CR	16	1.2	1.5	11.2	7.5	No	—	—
29	F	73	GBM	Prim	No	NA	CR	17	1.2	1.2	49.1	6.8	No	—	—
30	M	86	AII	Rec	S/R/Ch	NA	CR	17	1.0	1.3	8.8	6.0	No	—	—
31	F	53	GBM	Rec	S/R/Ch	IR	IR	18	1.1	1.8	13.0	33.0	Local	1.45	1.97
32	F	45	OAII	Rec	S	IR	IR	18	1.1	1.4	50.9	39.8	No	2.63	2.34
33	F	38	OIII	Rec	S/Ch	IR	IR	18	0.9	1.9	19.0	30.9	Distant	1.54	2.91
34	M	68	GBM	Prim	No	IR	IR	18	1.4	3.2	67.5	146.5	Distant	1.99	5.01
35	M	66	GBM	Rec	S/R/Ch	NA	IR	19	0.9	1.2	28.3	42.5	Distant	1.74	2.81
36	M	37	OII	Rec	S/Ch	IR	IR	20	1.3	2.0	25.3	35.0	Local	1.15	2.08
37	F	63	AIII	Prim	No	IR	IR	21	1.0	1.4	6.9	17.4	Local	1.38	2.49
38	M	72	AIII	Rec	S/R/Ch	IR	IR	21	0.9	1.8	96.5	153.5	Local	1.84	2.93
39	F	79	GBM	Rec	S/R/Ch	IR	IR	21	1.2	1.4	2.6	4.2	Distant	0.86	1.46
40	F	62	GBM	Prim	S/R/Ch	IR	CR	26	1.0	1.3	13.3	9.9	No	—	—
41	M	55	OAIII	Rec	S/R/Ch	IR	CR	27	1.0	1.5	8.1	16.0	No	—	—
42	M	51	GBM	Rec	S/R/Ch	CR	CR	28	1.5	1.7	85.9	45.2	No	—	—
43	F	57	AIII	Prim	No	IR	IR	28	1.1	1.6	14.4	10.0	No	2.40	2.39

Histo = histologic findings; prim/rec = untreated primary tumor/recurrent tumor; LBR_max rim = lesion-to-brain ratio of ¹⁸F-FET uptake at rim of resection cavity; BTV = BTV with TBR > 1.6; OP = operative; TBR_max = maximum tumor-to-brain ratio; A = astrocytoma; GBM = glioblastoma; O = oligodendroglioma; OA = oligoastrocytoma; I–III = tumor grade according to World Health Organization classification 2007; S = surgery; Ch = chemotherapy; R = radiotherapy; NA = not applicable; local/distant flare phenomenon = prominent increase in ¹⁸F-FET uptake after surgery in area of tumor tissue with increased ¹⁸F-FET uptake in preoperative scan (local) or in area distant from that location.