TABLE 2

Results of iPET Interpretation Using Different Definitions of iPET+

Definition of iPET+	Patients (n)	TN/FN/TP/FP (n)	Sensitivity (%)	Specificity (%)	NPV (%)	PPV (%)	Accuracy (%)	iPET− 3-y PFS (%)	iPET+ 3-y PFS (%)	P (log-rank)
Visual
5-PS = 3–5	145 (100%)	51/6/35/53	85.4	49.0	89.5	39.8	59.3	91.3	60.26	<0.001
5-PS = 4–5	145 (100%)	82/10/31/22	75.6	78.8	89.1	58.5	77.9	90.2	41.6	<0.001
5-PS = 5	145 (100%)	101/23/18/3	43.9	97.1	81.5	85.7	82.1	82.3	14.4	<0.001
Semiquantitative
ΔSUV_max < 76.4%	145 (100%)	83/16/25/21	61.0	79.8	83.8	54.3	74.5	84.9	45.6	<0.001
ΔSUV_max < 66%	145 (100%)	99/25/16/5	39.0	95.2	79.8	76.2	79.3	80.6	23.9	<0.001
ΔSUV_max < 48.9%^*	145 (100%)	104/31/10/0	24.4	100.0	77.0	100.0	78.6	77.7	0	<0.001
Combined^†
5-PS = 4–5; ΔSUV_max < 66%	107 (73.8%)	80/9/15/3	62.5	96.4	89.9	83.3	88.8	91.0	16.8	<0.001
5-PS = 4–5; ΔSUV_max < 48.9%	102 (70.3%)	82/10/10/0	50.0	100.0	89.1	100.0	90.2	90.2	0	<0.001

↵* ΔSUV_max = 48.9%: cutoff for 100% specificity based on ROC analysis.
↵† iPET is positive if both visually (5-PS = 4–5) and quantitatively positive; iPET is negative if negative with both methods.
TN = true-negative; FN = false-negative; TP = true-positive; FP = false-positive.