TABLE 1

Radionuclide Tracers for Imaging of Amyloidosis

TracerMolecular targetDisease target
SPECT tracers
 Bone-seeking radiotracersPhosphate bindersATTR
  99mTc-pyrophosphate
  99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid
  99mTc-hydroxymethylene diphosphonate
 Other radiotracers
  123I-serum amyloid proteinSerum amyloid PAll amyloidoses
  123I-aprotininSerum protease inhibitor, amyloid binderAll amyloidoses
PET tracers
 Thioflavin-T derivativesAll amyloid fibrils (β-structure and side chains)AL and ATTR
  18F-florbetapir
  18F-florbetaben
  18F-flutemetamol
  11C-Pittsburgh compound B
  18F-sodium fluorideMicrocalcificationATTR
  124I-m11-1F4 monoclonal antibodyImmunoglobulin ALsAL