Patient Characteristics and Association Between HPD and Categoric Variables
| Characteristic | All patients (n = 46) | Non-HPD (n = 32) | HPD (n = 14) | P |
| Age (y) | >0.99 | |||
| <73 | 22 (47.8%) | 15 (46.9%) | 7 (50%) | |
| ≥73 | 24 (52.2%) | 17 (53.1%) | 7 (50%) | |
| Sex | 0.30 | |||
| Male | 32 (69.6%) | 24 (75%) | 8 (57.1%) | |
| Female | 14 (30.4%) | 8 (25%) | 6 (42.9%) | |
| Smoking status | >0.99 | |||
| Current/former | 41 (89.1%) | 28 (87.5%) | 13 (92.9%) | |
| Never | 5 (10.9%) | 4 (12.5%) | 1 (7.1%) | |
| Previous lines of treatment | 0.71 | |||
| 0 | 12 (26.1%) | 8 (75.0%) | 4 (57.1%) | |
| ≥1 | 34 (73.9%) | 24 (31.3%) | 10 (28.6%) | |
| Metastatic sites (median) | <0.001 | |||
| ≤2 | 26 (69.6%) | 24 (75%) | 2 (14.3%) | |
| >2 | 20 (30.4%) | 8 (25%) | 12 (85.7%) | |
| Histology | >0.99 | |||
| Nonsquamous | 34 (73.9%) | 24 (75%) | 10 (71.4%) | |
| Squamous | 12 (26.1%) | 8 (25%) | 4 (28.6%) | |
| Tumor PD-L1 status | 0.67 | |||
| Negative | 9 (19.6%) | 5 (15.6%) | 4 (28.6%) | |
| Positive | 16 (34.8%) | 11 (34.4%) | 5 (35.7%) | |
| Missing | 21 (45.6%) | 16 (50%) | 5 (35.7%) |