TABLE 3

Cox Regressions of Survival and Biomarkers

Cox regression	Covariates	HR	95% CI	P
Univariate	Whole-body PSMA_TV50	1.004	1.001–1.006	0.002
	Whole-body PSMA_LA	1.000	1.000–1.000	0.077
	Whole-body SUV_max	0.997	0.985–1.008	0.583
	Whole-body SUV_peak	0.995	0.976–1.013	0.573
	Whole-body SUV_mean	0.977	0.924–1.033	0.411
	ALP	1.001	1.000–1.003	0.047
	PSA	1.000	1.000–1.001	0.066
Multivariate	Whole-body PSMA_TV50	1.004	1.001–1.006	0.004
	ALP	1.001	1.000–1.003	0.115

PSMA_TV = volume of PSMA-positive tumor (mL); PSMA_LA = volume of PSMA-positive tumor multiplied by SUV_mean; PSA = prostate-specific antigen; ALP = alkaline phosphatase.