TABLE 1

PPP Criteria

Progression criterionExplanation
2 or more new PSMA-positive lesionsAppearance of 2 or more new PSMA-positive distant lesions
1 new PSMA-positive lesionAppearance of 1 new PSMA-positive lesion plus consistent clinical or laboratory data and recommended confirmation by biopsy or correlative imaging within 3 mo of PSMA PET
No new lesions but size increaseIncrease by ≥30% in size or uptake plus consistent clinical or laboratory data and confirmation by biopsy or correlative imaging within 3 mo of PSMA PET