Patient and Tumor Characteristics
| Characteristic | CRM evaluation (n = 8)* | Fluorescence cutoff value determination (n = 17)* |
| Sex | ||
| Male | 5 (62.5) | 12 (70.6) |
| Female | 3 (37.5) | 5 (29.4) |
| Age (y)† | 56 (54–61) | 56 (31–76) |
| Duration between nCRT and surgery (d)‡ | 87 (76–111) | 87 (77–117) |
| Surgery | ||
| Low anterior resection | 5 (62.5) | 10 (58.8) |
| Including adjacent organs | 1 | 2 |
| Abdominal–perineal resection | 3 (37.5) | 7 (41.2) |
| Including adjacent organs | 3 | 5 |
| IORT | ||
| Not standby | 3 (37.5) | |
| Standby | 4 (50) | |
| Applied | 1 (12.5) | |
| Histopathologic staging | ||
| pT0N0M0 (pCR) | 1 (12.5) | 1 (5.9) |
| pT2N0M0 | 2 (25.0) | 2 (11.8) |
| pT3N0M0 | 1 (12.5) | 4 (23.5) |
| pT3N1M0 | 0 | 3 (17.6) |
| pT3N2M0 | 2 (25.0) | 5 (29.4) |
| pT4N0M0 | 2 (25.0) | 2 (11.8) |
| CRM | ||
| ≤1 mm (tumor-positive) | 2 (25.0) | 3 (17.6) |
| 1–2 mm | 1 (12.5) | 2 (11.8) |
| >2 mm | 4 (50.0) | 11 (64.7) |
| pCR | 1 (12.5) | 1 (5.9) |
| Distal resection margin | ||
| ≤1 mm (tumor-positive) | 0 | 0 |
| 1–2 mm | 0 | 1 (5.9) |
| >2 mm | 7 (87.5) | 15 (88.2) |
| pCR | 1 (12.5) | 1 (5.9) |