Absorbed Radiation Doses of 177Lu-PP-F11N in Tumors, Kidneys, Stomach, and Bone Marrow Without and With Coadministration of SG
Mean tumor dose (Gy/GBq)/patient | Mean kidney dose (Gy/GBq)/patient | Stomach dose (Gy/GBq) | Bone marrow dose (Gy/GBq) | Tumor-to-kidney dose ratio | Tumor-to-stomach dose ratio | Tumor-to-bone marrow dose ratio | ||||||||
Patient | Without SG | With SG | Without SG | With SG | Without SG | With SG | Without SG | With SG | Without SG | With SG | Without SG | With SG | Without SG | With SG |
1 | 1.09 | 1.04 | 0.15 | 0.11 | 0.45 | 0.50 | 0.022 | 0.025 | 7.27 | 9.45 | 2.42 | 2.08 | 49.6 | 41.6 |
2 | 3.59 | 1.42 | 0.13 | 0.07 | 0.38 | 0.47 | 0.025 | 0.028 | 27.6 | 20.3 | 9.45 | 3.02 | 143.6 | 50.7 |
3 | 0.90 | 0.67 | 0.06 | 0.05 | 1.66 | 1.46 | 0.028 | 0.031 | 15.0 | 13.4 | 0.54 | 0.46 | 32.1 | 21.6 |
4 | 0.85 | 0.64 | 0.08 | 0.10 | 0.20 | 0.18 | 0.044 | 0.039 | 10.6 | 6.4 | 4.25 | 3.56 | 19.3 | 16.4 |
5 | 0.85 | 1.03 | 0.13 | 0.05 | 1.2 | 2.07 | 0.036 | 0.039 | 6.5 | 20.6 | 0.71 | 0.50 | 23.6 | 26.4 |
6 | 0.63 | 0.63 | 0.05 | 0.05 | 0.13 | 0.26 | 0.028 | 0.033 | 12.6 | 12.6 | 4.85 | 2.42 | 22.5 | 19.1 |
Median | 0.88 | 0.85 | 0.11 | 0.06 | 0.42 | 0.49 | 0.028 | 0.032 | 11.6 | 13.0 | 3.34 | 2.25 | 27.9 | 24.0 |
IQR | 0.85–1.04 | 0.65–1.04 | 0.07–0.13 | 0.05–0.09 | 0.25–1.01 | 0.31–1.22 | 0.026–0.034 | 0.025–0.038 | 8.11–14.4 | 10.2–18.6 | 1.14–4.70 | 0.90–2.87 | 19.3–45.2 | 16.4–37.8 |
Test for superiority(P)* | 0.38 | 0.38 | 0.69 | 0.22 | 1.0 | 0.16 | 0.22 |
↵* Two-sample paired sign test with significance level (α) of 0.05.