TABLE 1

Proposed Clinical Algorithm for Nuclear Imaging Investigations in Cases of PPGL (10)

ConditionFirst choiceSecond choice
Pheochromocytoma (apparently sporadic)18F-FDOPA or 123I-MIBG68Ga-SSA
Inherited pheochromocytoma (except SDHx): NF1/RET/VHL/MAX18F-FDOPA123I-MIBG or 68Ga-SSA
HNPGL68Ga-SSA18F-FDOPA
Extraadrenal sympathetic or multifocality or metastatic disease or SDHx mutation68Ga-SSA18F-FDG and 18F-FDOPA
  • MIBG = metaiodobenzylguanidine; SSA = somatostatin analog.