TABLE 1

Whole-Body Distribution After Intravenous Administration of ²²⁵Ac-FAPI-04 in PANC-1 Xenograft Model

	%ID		%ID/g
Site	3 h	24 h	3 h	24 h
Brain	0.015 ± 0.004	0.004 ± 0.001	0.047 ± 0.007	0.015 ± 0.004
Submandibular gland	0.034 ± 0.004	0.010 ± 0.001	0.282 ± 0.059	0.083 ± 0.020
Heart	0.031 ± 0.005	0.001 ± 0.003	0.277 ± 0.041	0.013 ± 0.030
Lung	0.028 ± 0.008	0.008 ± 0.005	0.128 ± 0.032	0.041 ± 0.023
Liver	0.745 ± 0.005	0.443 ± 0.032	0.685 ± 0.042	0.374 ± 0.037
Stomach	0.028 ± 0.007	0.009 ± 0.004	0.224 ± 0.060	0.096 ± 0.042
Small intestine	0.229 ± 0.036	0.048 ± 0.008	0.275 ± 0.050	0.055 ± 0.003
Large intestine	0.025 ± 0.005	0.014 ± 0.003	0.434 ± 0.108	0.098 ± 0.019
Kidney	1.117 ± 0.133	0.312 ± 0.022	3.274 ± 0.565	0.883 ± 0.106
Adrenal gland	0.025 ± 0.004	0.005 ± 0.002	1.492 ± 0.186	0.323 ± 0.077
Pancreas	0.029 ± 0.001	0.017 ± 0.008	0.310 ± 0.012	0.140 ± 0.068
Spleen	0.029 ± 0.004	0.018 ± 0.002	0.203 ± 0.006	0.106 ± 0.020
Testis	0.014 ± 0.001	0.007 ± 0.001	0.079 ± 0.008	0.034 ± 0.003
Urine	2.816 ± 2.775	0.073 ± 0.060	40.66 ± 40.25	1.343 ± 0.439
Blood	0.051 ± 0.008	0.024 ± 0.011	0.102 ± 0.021	0.041 ± 0.017
Bone	0.052 ± 0.004	0.027 ± 0.003	0.161 ± 0.007	0.085 ± 0.009
Bone marrow	0.011 ± 0.003	0.003 ± 0.005	0.175 ± 0.082	0.025 ± 0.042
Muscle	0.051 ± 0.011	0.027 ± 0.004	0.061 ± 0.008	0.030 ± 0.001
Tumor	0.173 ± 0.029	0.092 ± 0.023	0.251 ± 0.010	0.097 ± 0.008
Excrement (urine)	88.87 ± 2.81	91.23 ± 13.05	NA	NA
Excrement (feces)	NA	2.102 ± 0.101	NA	NA

%ID = percentage injected dose; NA = not available.
Data are mean ± SE (n = 6).