Timing | 123I-MIBG SPECT/CT | 18F-DOPA PET/CT | P* |
Before induction chemotherapy | |||
Soft-tissue metastases | 20 (41%) | 42 (86%) | <0.001 |
Bone or bone-marrow metastases | 494 (93%) | 522 (99%) | <0.001 |
After induction chemotherapy | |||
Soft-tissue metastases | 11 (28%) | 30 (77%) | <0.001 |
Bone or bone-marrow metastases | 54 (69%) | 67 (86%) | 0.001 |
↵* Exact McNemar significance probability.
DRs (%) were calculated for each single diagnostic modality at each site of disease. Denominator for DRs is maximum number of lesions found to be positive by 2 diagnostic modalities: n = 49 and n = 39 before and after induction chemotherapy, respectively, for soft tissue; n = 529 and n = 78 before and after induction chemotherapy, respectively, for bone or bone-marrow lesions.