TABLE 2

Biodistribution Studies in PC-3 Tumor–Bearing SCID Mice

Tissue4 h24 h72 h
177Lu-E-AG
 Blood0.07 ± 0.070.02 ± 0.020.01 ± 0.02
 Liver0.44 ± 0.160.46 ± 0.130.42 ± 0.09
 Pancreas41 ± 1234 ± 526.3 ± 1.5
 Stomach0.9 ± 0.50.4 ± 0.20.40 ± 0.06
 Spleen*0.017 ± 0.0030.04 ± 0.040.03 ± 0.01
 Small intestine*1.9 ± 0.71.73 ± 0.081.13 ± 0.17
 Kidney10 ± 310 ± 37.1 ± 0.9
 Tumor3.3 ± 1.13.0 ± 0.42.06 ± 0.16
 Muscle0.04 ± 0.060.02 ± 0.020.06 ± 0.06
 Bone0.4 ± 0.30.5 ± 0.20.28 ± 0.09
177Lu-C-AG
 Blood0.02 ± 0.020.03 ± 0.040.01 ± 0.01
 Liver0.22 ± 0.050.18 ± 0.060.10 ± 0.04
 Pancreas41 ± 1831 ± 617.6 ± 0.4
 Stomach0.47 ± 0.110.33 ± 0.020.10 ± 0.03
 Spleen*0.05 ± 0.050.03 ± 0.030.10 ± 0.03
 Small intestine*2.1 ± 0.40.86 ± 0.180.40 ± 0.05
 Kidney6 ± 23.8 ± 1.41.09 ± 0.10
 Tumor2.9 ± 0.41.8 ± 0.30.94 ± 0.14
 Muscle0.06 ± 0.060.03 ± 0.050.02 ± 0.02
 Bone0.01 ± 0.010.03 ± 0.050.08 ± 0.08
177Lu-E-AN
 Blood0.01 ± 0.010.04 ± 0.030.02 ± 0.02
 Liver0.55 ± 0.070.66 ± 0.120.4 ± 0.2
 Pancreas1.1 ± 0.30.7 ± 0.50.5 ± 0.2
 Stomach0.41 ± 0.190.11 ± 0.060.02 ± 0.03
 Spleen*0.01 ± 0.020.02 ± 0.020.02 ± 0.01
 Small intestine*0.26 ± 0.130.13 ± 0.020.05 ± 0.03
 Kidney7.4 ± 0.96.7 ± 1.43.7 ± 1.8
 Tumor11.9 ± 1.76.3 ± 0.63.8 ± 0.7
 Muscle0.15 ± 0.140.21 ± 0.180.15 ± 0.17
 Bone0.21 ± 0.160.6 ± 0.20.2 ± 0.3
177Lu-C-AN
 Blood0.2 ± 0.20.02 ± 0.030.007 ± 0.004
 Liver0.63 ± 0.180.26 ± 0.140.22 ± 0.05
 Pancreas1.5 ± 1.00.4 ± 0.40.10 ± 0.09
 Stomach0.5 ± 0.40.03 ± 0.030.02 ± 0.03
 Spleen*0.02 ± 0.010.02 ± 0.020.01 ± 0.01
 Small intestine*0.26 ± 0.090.08 ± 0.030.02 ± 0.02
 Kidney5.4 ± 1.71.6 ± 0.40.7 ± 0.2
 Tumor13 ± 33.8 ± 0.51.9 ± 0.5
 Muscle0.13 ± 0.130.2 ± 0.40.03 ± 0.03
 Bone0.6 ± 0.30.5 ± 0.90.07 ± 0.07

  • ↵* Data are represented as %ID.

  • Data are mean %ID/g ± SD (n ≥ 4) unless otherwise noted.