Synergy Test of Interactions Between BRAF V600E and TERT Promoter Mutations in Their Effect on Loss of RAI Avidity in Recurrent PTC
| Risk of loss of radioiodine avidity | |||
| TERT mutation | PTC type | Synergy index | P |
| C228T and C250T | All PTC | 13.28 (1.54–114.46) | 0.019 |
| CPTC | – | – | |
| C228T only | All PTC | 10.99 (1.28–94.06) | 0.029 |
| CPTC | – | – | |
Synergy index for risk of loss of radioiodine avidity could not be calculated for conventional PTC (CPTC) because loss of radioiodine avidity occurred in all of cases harboring genetic duet of coexisting BRAF and TERT mutations. Data in parentheses are 95% CIs.