TABLE 1

Experience with PRRT by Site of Primary Tumor

AuthorYearPatients*TreatmentORRPFSOS
Midgut NETs (grade 9)
 Strosberg (7)2017116177Lu-DOTATATE18%, 18/101NRNR
 Sabet (3)201561177Lu-DOTATATE13%, 8/613361
  Hörsch (5)2016138177Lu-DOTATATE 90Y-DOTATOCNR51NR
 Brabander (4)2017181177Lu-DOTATATE31%, 57/1813060
 Baum (6)2018315177Lu-DOTATATE 90Y-DOTATOCNR2269
Pancreatic NETs (grade 8)
 Baum (6)2018315177Lu-DOTATATE 90Y-DOTATOCNR2044
 Hörsch (5)2016172177Lu-DOTATATE 90Y-DOTATOCNR3953
 Brabander (4)2017133177Lu-DOTATATE55%, 72/1333071
 Ezziddin (10)201468177Lu-DOTATATE60%, 41/683453
 Sansovini (53)201760177Lu-DOTATATE30%, 18/6029NR
 Garske-Román (9)201848177Lu-DOTATATE45%, 22/49NRNR
Bronchial carcinoid (before everolimus grade 6;  after everolimus grade 7)
 Mariniello (54)2016114177Lu-DOTATATE 90Y-DOTATOC13%, 15/1142859
 Baum (6)201875177Lu-DOTATATE 90Y-DOTATOCNR1140
 Ianniello (55)201734177Lu-DOTATATE15%, 4/321949
 Brabander (4)201723177Lu-DOTATATE30%, 7/232052
 Parghane (56)201722177Lu-DOTATATE11%, 2/19NR40
 Sabet (57)201722177Lu-DOTATATE27%, 6/222742
Unknown primary tumor (grade 8)
 Baum (6)2018151177Lu-DOTATATE 90Y-DOTATOCNR1353
 Brabander (4)201782177Lu-DOTATATE35% 29/822953
 Delpassand (58)20147177Lu-DOTATATENR11NR
 Bodei (11)20113177Lu-DOTATATE0% 0/3NRNR
Paraganglioma/pheochromocytoma  (MIBG positive grade 5; MIBG negative grade 7)
 Forrer (17)200828177Lu-DOTATATE 90Y-DOTATOC7%, 2/28NRNR
 Kong (18)201720177Lu-DOTATATE29%, 5/1739NR
 van Essen (16)200612177Lu-DOTATATE17%, 2/12NRNR
  • * Only within NET subtype (n).

  • ORR = overall response rate; PFS = progression free survival (in months); OS = overall survival (in months); NR = not reported/reached.