TABLE 1

Growth Delay of Human Breast Cancer Xenografts

²²³RaCl₂ treatment (kBq/kg)	D_bone (Gy)^*	D_marrow (Gy)^*	D_bystander (Gy)^*	r_o,bystander (Gy/h)^†	Doubling time (days)		Growth delay (days)
²²³RaCl₂ treatment (kBq/kg)	D_bone (Gy)^*	D_marrow (Gy)^*	D_bystander (Gy)^*	r_o,bystander (Gy/h)^†	MCF-7	MDA-MB-231	MCF-7	MDA-MB-231
0	0	0	0	0	20	23	0	0
50	D_α = 1.74	D_α = 0.11	D_α = 0.01–0.03	0.58–1.2 × 10⁻⁴	27	9.4	7	−14
	D_β = 0.04	D_β = 0.01	D_β = 0.01–0.013
	D_tot = 1.8	D_tot = 0.12	D_tot = 0.02–0.04
600	D_α = 20.9	D_α = 1.36	D_α = 0.12–0.32	0.67–1.3 × 10⁻³	86	33	65	10
	D_β = 0.44	D_β = 0.13	D_β = 0.11–0.16
	D_tot = 21	D_tot = 1.5	D_tot = 0.23–0.48

↵* Absorbed dose for complete decay (integrated to t = ∞).
↵† Initial dose rate r_o to bystander compartment.
D_α = absorbed dose from alpha particles; D_β = absorbed dose from beta particles; D_tot = D_α + D_β.
Doubling time and growth delay are as defined by Demidenko (34).