TABLE 2

Age Effects on Volumetric and PET Outcome Measures

	%Vol_roi			¹⁸F-BCPP-EF			¹¹C-SA-4503			¹¹C-UCB-J
ROI	r	P	∆/y	r	P	∆/y	r	P	∆/y	r	P	∆/y
Centrum semiovale	0.26	0.42	0.2	−0.03	0.92	−0.05	0.02	0.95	0.05	−0.13	0.68	−0.13
Brain stem	0.14	0.65	0.05	−0.16	0.63	−0.21	−0.22	0.49	−0.35	−0.44	0.15	−0.41
Substantia nigra	−0.33	0.29	−0.17	0.02	0.94	0.03	−0.38	0.23	−0.62	−0.36	0.25	−0.28
Thalamus	0.16	0.62	0.07	−0.46	0.13	−0.74	−0.29	0.36	−0.49	−0.74	0.01^*	−0.93
Ventral striatum	−0.18	0.57	−0.09	−0.25	0.44	−0.39	−0.24	0.45	−0.4	−0.62	0.03^*	−0.63
Caudate	0.46	0.14	0.39	−0.65	0.02^*	−1.68	−0.35	0.26	−0.77	−0.82	0.001^†	−1.83
Putamen	−0.51	0.09	−0.27	−0.14	0.67	−0.21	−0.02	0.94	−0.03	−0.44	0.16	−0.39
Hippocampus	−0.48	0.11	−0.33	−0.27	0.4	−0.39	−0.17	0.6	−0.19	−0.61	0.04^*	−0.59
Insular cortex	−0.41	0.19	−0.28	−0.26	0.41	−0.35	−0.21	0.52	−0.26	−0.6	0.04^*	−0.48
Temporal lobe	−0.71	0.01^*	−0.51	−0.26	0.42	−0.35	−0.2	0.54	−0.25	−0.55	0.06	−0.44
Parietal lobe	−0.77	0.003^†	−0.36	−0.32	0.31	−0.52	−0.17	0.61	−0.24	−0.61	0.03^*	−0.69
Frontal cortex	−0.75	0.01^*	−0.53	−0.35	0.27	−0.52	−0.23	0.47	−0.43	−0.65	0.02^*	−0.69
Cerebellum	−0.45	0.14	−0.25	0.02	0.96	0.02	−0.23	0.47	−0.33	−0.13	0.68	−0.11

↵* P < 0.05.
↵† P < 0.005.