TABLE 1

Results from Logit TCP Models

Dose metric	−2logL	AUC	50% TCP	90% TCP	Sensitivity	Specificity	Dose metric P
Mean dose	394.2	0.884	292 Gy	554 Gy	0.750	0.889	0.014
AD30	395.7	0.896	354 Gy	650 Gy	0.792	0.833	0.012
V500 (AD)	388.4	0.872	18%	51%	0.750	0.889	0.109
EUD, α = 0.0001 Gy⁻¹	394.2	0.882	291 Gy	552 Gy	0.750	0.889	0.014
EUD, α = 0.0002^*Gy⁻¹	394.1	0.880	290 Gy	551 Gy	0.750	0.889	0.014
EUD, α = 0.0005 Gy⁻¹	394.2	0.877	286 Gy	546 Gy	0.750	0.889	0.014
EUD, α = 0.002 Gy⁻¹	395.5	0.873	269 Gy	520 Gy	0.750	0.826	0.014
Mean BED	409.8	0.869	441 Gy	953 Gy	0.760	0.889	0.007
BED50	399.7	0.896	406 Gy	840 Gy	0.750	0.889	0.008
V500 (BED)	389.0	0.866	33.2%	79%	0.875	0.833	0.074
EUBED, α = 0.0001 Gy⁻¹	397.8	0.903	463 Gy	890 Gy	0.750	0.889	0.008
EUBED, α = 0.0005^*Gy⁻¹	396.2	0.903	442 Gy	856 Gy	0.750	0.889	0.009
EUBED, α = 0.0008 Gy⁻¹	396.6	0.905	427 Gy	832 Gy	0.750	0.889	0.009
EUBED, α = 0.002 Gy⁻¹	398.6	0.884	380 Gy	754 Gy	0.750	0.826	0.009

↵* Maximum likelihood value of α.
−2logL = log likelihood.
All AUCs were statistically significant, with P < 0.0001; 50% and 90% TCP are value of dose metric corresponding to 50% and 90% predicted TCP, respectively. Dose metric P is P value of dose metric from logistic model. Sensitivity and specificity were calculated using 50% TCP as cutoff for predicted response. Supplemental Table 6 shows results corresponding to full range of α values tested.