Comparison of Parameters Between Responders (n = 16; 25.8%) and Nonresponders (n = 46; 74.2%)
| T1 (n = 63) | T2 (n = 60) | Change*(n = 60) | |||||||
| Parameter | Nonresponders | Responders | P | Nonresponders | Responders | P | Nonresponders | Responders | P |
| Conventional indices | |||||||||
| SUVmax | 8.51 (0.51) | 9.13 (0.81) | 0.52 | 6.44 (2.72) | 6.09 (2.75) | 0.739 | −18.73 (4.53) | −31.94 (5.85) | 0.128 |
| SUVpeak | 6.98 (3.29) | 7.72 (2.73) | 0.394 | 5.11 (2.51) | 4.25 (3.06) | 0.283 | −22.89 (31.23) | −47.19 (32.00) | 0.007 |
| TLG | 158.90 (204.55) | 231.05 (226.52) | 0.085 | 95.92 (134.86) | 66.51 (68.97) | 0.318 | −22.56 (51.07) | −72.19 (20.52) | 0.0003 |
| CoV | 0.27 (0.14) | 0.28 (0.07) | 0.204 | 0.23 (0.11) | 0.20 (0.06) | 0.447 | −12.45 (20.87) | −26.62 (22.02) | 0.029 |
| MTV | 37.59 (55.56) | 46.6 (37.04) | 0.077 | 28.99 (50.53) | 17.47 (17.03) | 0.447 | −17.36 (48.35) | −65.64 (23.23) | 0.0001 |
| Histogram indices | |||||||||
| Skewness | 0.5 (0.4) | 0.3 (0.4) | 0.016 | 0.42 (0.38) | 0.33 (0.33) | 0.417 | 10.03 (171.29) | 105.63 (344.67) | 0.545 |
| Kurtosis | 3.0 (1.3) | 2.7 (0.7) | 0.048 | 2.98 (0.84) | 2.73 (0.39) | 0.37 | 3.50 (23.57) | 4.56 (15.39) | 0.872 |
| Entropy(log2) | 3.7 (0.6) | 4.0 (0.5) | 0.144 | 3.23 (0.77) | 3.09 (0.82) | 0.56 | −12.77 (17.02) | −23.22 (16.71) | 0.043 |
| Energy | 0.10 (0.04) | 0.07 (0.03) | 0.172 | 0.14 (0.08) | 0.16 (0.09) | 0.591 | 54.89 (80.49) | 112.55 (96.27) | 0.019 |
| Shape indices | |||||||||
| Sphericity | 0.99 (0.16) | 0.95 (0.26) | 0.515 | 0.94 (0.30) | 0.81 (0.42) | 0.242 | −5.59 (26.35) | −19.55 (41.74) | 0.389 |
| Compacity | 1.7 (0.7) | 1.9 (0.7) | 0.063 | 1.45 (0.73) | 1.19 (0.74) | 0.427 | −15.02 (30.21) | −44.58 (31.80) | 0.0005 |
| GLCM | |||||||||
| Contrast | 0.41 (0.09) | 0.39 (0.08) | 0.436 | 0.43 (0.16) | 0.38 (0.22) | 0.62 | 8.16 (35.71) | −3.09 (54.03) | 0.783 |
| Correlation | 0.02 (0.01) | 0.01 (0.01) | 0.159 | 0.03 (0.03) | 0.03 (0.03) | 0.765 | 114.29 (238.48) | 171.28 (216.00) | 0.3001 |
| Entropy(log2) | 0.55 (0.15) | 0.60 (0.13) | 0.277 | 0.44 (0.20) | 0.40 (0.25) | 0.713 | −14.08 (54.67) | −33.26 (45.40) | 0.183 |
| Dissimilarity | 2.02 (0.33) | 2.17 (0.25) | 0.118 | 1.65 (0.64) | 1.41 (0.81) | 0.301 | −17.09 (27.48) | −36.68 (35.00) | 0.022 |
| NGLDM | |||||||||
| Coarseness | 524.33 (643.33) | 704.76 (518.63) | 0.026 | 342.81 (487.42) | 222.71 (227.81) | 0.334 | −28.55 (51.36) | −71.44 (24.14) | 0.0006 |
| Contrast | 0.89 (0.05 | 0.90 (0.04) | 0.885 | 0.79 (0.26) | 0.69 (0.36) | 0.37 | −8.88 (25.71) | −22.59 (40.27) | 0.123 |
| Busyness | 0.02 (0.016) | 0.02 (0.011) | 0.074 | 0.027 (0.021) | 0.025 (0.023) | 0.626 | 52.41 (143.84) | 119.57 (178.80) | 0.057 |
↵* Percentage change calculated by 100 × [(value at T2 − value at T1)/value at T1].
MTV = metabolic tumor volume; NGLDM = neighboring gray-level dependence matrix.
Data are mean followed by SD in parentheses.