Prognostic Potential of Different Models Trained in Training Cohort and Evaluated in Validation and Merged Groups
| Model | Training (n = 15) | Validation (n = 22) | Merged (n = 37) |
| MFMISO/TCP | |||
| Concordance | 0.77 (0.67–0.82) | 0.71 (0.64–0.77) | 0.74 (0.71–0.77) |
| P | 0.001* | 0.004* | <0.0001* |
| HR | 17.0 (1.9–143) | 6.7 (1.5–30) | 9.4 (2.9–31) |
| rHV | |||
| Concordance | 0.57 (0.36–0.57) | 0.63 (0.58–0.67) | 0.61 (0.57–0.67) |
| P | 0.269 | 0.001* | 0.020 |
| HR | — | 8.6 (0.22–331) | — |
| TMRmax | |||
| Concordance | 0.58 (0.40–0.62) | 0.60 (0.47–0.61) | 0.61 (0.54–0.68) |
| P | 0.435 | 0.028 | 0.043 |
| HR | — | — | — |
| GTV | |||
| Concordance | 0.67 (0.62–0.77) | 0.53† | 0.60 (0.52–0.66) |
| P | 0.083 | 0.317 | 0.031 |
| HR | — | — | — |
| LogitTMR-V | |||
| Concordance | 0.73 (0.70–0.85) | 0.58 (0.53–0.62) | 0.65 (0.62–0.70) |
| P | 0.010* | 0.1 | 0.001* |
| HR | 2.4 (0.56–11) | — | 3.1 (0.91–11) |
↵* P < 0.01.
↵† Confidence interval estimation not possible in this case.
rHV = relative hypoxic volume; logitTMR-V = logistic regression model trained for TMRmax and GTV.
Concordance index is for univariable Cox model. P values are for log-rank test regarding Kaplan–Meier analysis. Data in parentheses are 95% confidence intervals.