TABLE 1

Definitions of Screening Strategies

Screening strategy designationScreening strategy descriptionDefinition of positive imaging resultAfter positive imaging resultsAfter negative imaging results
1Standard biopsyN/A (no imaging)N/A; always standard biopsyN/A; always standard biopsy
2mpMRI alone (Likert scores)Likert 4–5Combined biopsyStandard biopsy
3mpMRI alone (PI-RADS scores)PI-RADSv2 3–5Combined biopsyStandard biopsy
418F-choline PET/mpMRI (Likert scores)Likert 5 mpMRI lesion or Likert 3–4 mpMRI lesion with 18F-choline TBR of ≥1.58*Combined biopsyStandard biopsy
518F-choline PET/mpMRI (PI-RADS scores)PI-RADS 5 mpMRI lesion or PI-RADS 3–4 mpMRI lesion with 18F-choline TBR of ≥1.58Combined biopsyStandard biopsy
6mpMRI alone (Likert scores)Likert 4–5Combined biopsyNo biopsy
7mpMRI alone (PI-RADS scores)PI-RADS 3–5Combined biopsyNo biopsy
818F-choline PET/mpMRI (Likert scores)Likert 5 mpMRI lesion or Likert 3–4 mpMRI lesion with 18F-choline TBR of ≥1.58Combined biopsyNo biopsy
918F-choline PET/mpMRI (PI-RADS scores)PI-RADS 5 mpMRI lesion or PI-RADS 3–4 mpMRI lesion with 18F-choline TBR of ≥1.58Combined biopsyNo biopsy

  • ↵* TBR threshold was defined in study by Piert et al. (8).

  • N/A = not applicable.