Patients’ Clinical Characteristics and Biochemical Investigation Results
| Patient | Age (y) | Sex | ISS-WM* | Cytogenetics† | M protein type | IgM (g/L) | M protein (g/L) | β2-microglobulin (mg/L) | sFLC (mg/L) |
| 1 | 69 | M | High | MYD88L265P | IgM λ | 66.99 | 47.7 | 9.54 | N/A |
| 2 | 69 | F | High | MYD88L265P | IgM κ | 28.93 | 17.5 | 4.85 | 64.7 (κ) |
| 3 | 56 | M | High | MYD88L265P | IgM κ | 25.32 | 13.1 | 9.28 | 33.8 (κ) |
| 4 | 61 | M | IND | MYD88L265P | IgM κ | 30.49 | 18.5 | 6.13 | 637.5 (κ) |
| 5 | 87 | M | High | MYD88L265P | IgM κ | 4.19 | 1.1 | 3.68 | 16.2 (κ) |
| 6 | 78 | F | High | MYD88 L265P | IgM κ | 18.81 | 10.8 | 12.8 | 365.0 (κ) |
| 7 | 72 | M | High | MYD88L265P | IgM κ | 5.78 | 2.1 | 8.93 | 1,629.1 (κ) |
| 8 | 56 | F | IND | MYD88L265P | IgM λ | 62.43 | 34.3 | 3.06 | N/A |
| 9 | 72 | M | IND | MYD88L265P | IgM λ | 15.2 | 10.5 | 3.27 | 27.2 (λ) |
| 10 | 60 | M | Low | MYD88L265PCXCR4s338x | IgM λ | 42.91 | 25.3 | 2.34 | 172.5 (λ) |
| 11 | 64 | M | IND | MYD88L265P | IgM λ | 23.69 | 10.6 | 5.71 | 151.3 (λ) |
| 12 | 64 | M | IND | MYD88L265P | IgM κ | 53.3 | 32.5 | 5.27 | 159.0 (κ) |
| 13 | 48 | F | N/A‡ | MYD88L265PCXCR4s338x | IgD κ | 6.67 (IgD)§ | N/A | N/A | 527.5 (κ) |
| 14 | 55 | F | Low | MYD88L265PCXCR4s338x | IgM κ | 82.49 | 35.6 | 2.93 | 25.7 (κ) |
| 15 | 52 | F | IND | MYD88L265P | IgM κ | 38.13 | 21.6 | 3.34 | 99.4 (κ) |
| 16 | 53 | M | IND | MYD88L265P | IgM λ | 20.13 | 13.9 | 3.57 | 89.2 (λ) |
| 17 | 48 | M | High | MYD88L265P | IgM κ | 77.67 | 47.4 | 6.6 | 6.5 (κ) |
↵* International Staging System (ISS) for WM (ISS-WM) prognostic scoring includes age of >65 y, ß2-microglobulin level of >3 mg/L, hemoglobin level of ≤11.5 g/dL, platelet count of ≤100 × 109/L, and IgM level of >7 g/dL. Low risk = ≤1 adverse characteristic and age of ≤65 y; high risk = ≥3 adverse characteristics; indeterminate (IND) risk = 2 adverse characteristics or age of >65 y.
↵† MYD88 and CXCR4 warts, hypogammaglobulinemia, infections, and myelokathexis syndrome–like somatic mutations were tested.
↵‡ ISS-WM scoring system was not applicable (N/A) for IgD-type WM/LPL.
↵§ Serum IgD level was measured as IgD-type M protein level.
sFLC = serum-free light chain; IND = indeterminate.