TABLE 1

Selected Ex Vivo Biodistribution Data for ¹⁸F-FBnTP and ¹⁸F-MitoPhos and Heart-to-Tissue Ratios

Tissue	5 min	15 min	30 min	60 min
¹⁸F-FBnTP
Blood	0.12 (0.22)	0.16 (0.06)	0.12 (0.06)	0.04 (0.01)
Plasma	0.56 (0.51)	0.08 (0.06)	0.05 (0.04)	0.02 (0.00)
Muscle	0.30 (0.12)	0.22 (0.12)	0.21 (0.04)	0.34 (0.14)
Spleen	5.63 (0.28)	4.58 (1.22)	3.17 (1.65)	2.49 (0.76)
Liver	3.71 (0.93)	3.57 (0.65)	3.58 (1.06)	3.59 (0.73)
Adrenals	6.87 (9.16)	9.84 (1.74)	11.33 (5.33)	7.00 (2.49)
Kidney	17.57 (5.27)	30.08 (3.81)	32.24 (3.44)	25.81 (5.92)
Lung	2.09 (0.38)	2.03 (0.12)	2.09 (0.27)	1.63 (0.47)
Heart	7.42 (0.43)	7.32 (0.69)	7.93 (2.45)	6.75 (1.54)
Brain	0.07 (0.03)	0.05 (0.01)	0.06 (0.02)	0.03 (0.01)
Heart-to-plasma	13.2 (12.0)	95.6 (70.9)	153.1 (135.2)	422.7 (142.5)
Heart-to-lung	3.6 (0.7)	3.6 (0.4)	3.8 (1.3)	4.1 (1.5)
Heart-to-liver	2.0 (0.5)	2.1 (0.4)	2.2 (0.9)	1.9 (0.6)
¹⁸F-MitoPhos
Blood	0.35 (0.17)	0.16 (0.02)	0.14 (0.02)	0.06 (0.02)
Plasma	0.19 (0.11)	0.06 (0.01)	0.07 (0.02)	0.02 (0.01)
Muscle	0.30 (0.04)	0.22 (0.02)	0.24 (0.06)	0.22 (0.06)
Spleen	6.67 (1.87)	6.04 (0.36)	7.28 (0.55)	4.231 (0.83)
Liver	3.91 (0.69)	2.25 (0.30)	1.53 (0.30)	0.463 (0.12)
Adrenals	12.50 (4.52)	11.32 (1.31)	21.16 (6.47)	14.30 (4.25)
Kidney	20.77 (1.63)	17.76 (0.28)	21.69 (1.37)	18.64 (4.57)
Lung	2.36 (0.15)	2.97 (1.42)	1.43 (0.25)	1.37 (0.36)
Heart	5.40 (0.61)	4.60 (0.32)	5.17 (0.56)	5.17 (0.86)
Brain	0.08 (0.01)	0.07 (0.00)	0.06 (0.01)	0.05 (0.01)
Heart-to-plasma	28.3 (16.6)	82.2 (15.7)	95.7 (36.9)	303.9 (185.8)
Heart-to-lung	2.3 (0.3)	1.6 (0.7)	3.6 (0.7)	3.8 (0.6)
Heart-to-liver	1.4 (0.5)	2.0 (0.2)	3.4 (0.8)	11.2 (1.2)

Data are average SUV (followed by SD in parentheses) determined by γ-counter measurement for each time point/min.