TABLE 4

Univariate and Multivariate Analysis of Prognostic Factors for PFS and CSS

	PFS						CSS
	Univariate			Multivariate			Univariate			Multivariate
Variable	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Presurgical
Sex (male vs. female)	0.75	0.27–2.06	0.57				0.78	0.24–2.56	0.68
Age (≤65 y vs. >65 y)	0.85	0.31–2.36	0.76				1.23	0.37–4.02	0.73
ECOG performance status (0 vs. 1–2)	0.52	0.18–1-46	0.21				0.45	0.13–1.54	0.19
Gunderson risk (intermediate/moderate vs. high)	0.68	0.23–2.01	0.49				0.50	0.13–1.89	0.29
Distance from anal verge (>5 cm vs. ≤5 cm)	0.41	0.13–1.28	0.11				0.50	0.13–1.96	0.20
Distance of mesorectal fascia (>2 mm vs. ≤2 mm)	0.56	0.19–1.66	0.29				0.43	0.11–1.62	0.20
Baseline CEA serum level (≤5 IU/L vs. >5 IU/L)	0.70	0.25–1.9	0.47				1.05	0.31–3.60	0.93
ΔTLG-early (≥59.5% vs. <59.5%)	0.26	0.07– 0.9	0.02	0.43	0.1–1.74	0.24	0.23	0.05–1.09	0.04	0.44	0.08–2.36	0.34
Postsurgical
TRG1 vs. TRG2–TRG4 or M1	0.25	0.05–1.13	0.05	1.07	0.13–8.8	0.94	0.17	0.02–1.39	0.06	0.27	0.03–2.53	0.25
yTNM (T0N0M0 vs. T1–T4 or N+ or M1)	0.15	0.02–1.19	0.04	0.22	0.01–3.62	0.29	0.24	0.03–1.91	0.14

CEA = carcinoembryonic antigen; ECOG = Eastern Cooperative Oncology Group; HR = hazard ratio.
Analysis for circumferential resection margin was not done because only 2 patients had positive margin (≤1 mm).