TABLE 1

AUCs* and Tumor–to–Normal-Organ Ratios for 68Ga-Labeled FAPI Derivatives

DerivativeAUC*Ratio
TumorBloodKidneyLiverMuscleTumor-to-bloodTumor-to-muscleTumor-to-liver
FAPI-0458.0229.5462.8419.0214.571.963.983.05
FAPI-2057.7539.7161.9230.0835.561.451.621.92
FAPI-2192.5940.1960.0142.2620.822.304.452.19
FAPI-2263.9540.3642.1833.9930.061.582.131.88
FAPI-3151.7639.7648.5334.3226.151.301.981.51
FAPI-3568.1135.5647.9621.8316.011.924.253.12
FAPI-3686.7475.3569.9238.2919.391.154.472.27
FAPI-3750.8241.1457.3828.4034.111.241.491.79
FAPI-4679.6327.2239.6717.8215.802.935.044.47
FAPI-5360.8528.8052.9117.4024.302.112.503.50
FAPI-55106.2052.7874.7542.9921.812.014.872.47
  • * Calculated from SUVmean 0–2 h after intravenous administration.

  • Calculated from AUC 0–2 h.