TABLE 1

Imaging Biomarkers

Biomarker classInformation provided (question answered)
DiagnosticIs the disease present?
PhenotypicWhat is the biologic behavior?
PrognosticWhat is the outcome?
PredictiveIs the therapeutic target expressed?
Intermediate endpointDoes the disease respond to treatment?
PharmacokineticWhat is the drug distribution?
PharmacodynamicIs the therapeutic target inhibited?