Pharmacokinetic Parameters of 111In-Nimotuzumab, 111In-Nimotuzumab-PEG6-DM1-Low, and 111In-Nimotuzumab-PEG6-DM1-High in Healthy BALB/c Mice
| Construct | Half-life t1/2α (h) | Half-life t1/2β (h) | AUC (%IA h/mL) | Vss (mL) | CL (mL/h × 10−2) |
| 111In-nimotuzumab | 2.3 ± 0.7 | 165 ± 29.6 | 1096.8 ± 6.3 | 19.3 ± 3.9 | 9.1 ± 1.0 |
| 111In-nimotuzumab-PEG6-DM1-Low | 17.6 ± 7.3 | 217.2 ± 24.7 | 2293.5 ± 299.9 | 10.9 ± 4.6 | 5.0 ± 1.0 |
| 111In-nimotuzumab-PEG6-DM1-High | 4.8 ± 0.1 | 433.1 ± 0.0 | 2791.6 ± 140.8 | 19.9 ± 1.0 | 4.0 ± 0.2 |
Data are mean values ± SEM.
Vss = volume of distribution at steady state; CL = clearance rate.